目的:本研究的目的是分析GLUT1-DS中的微态模式,生酮饮食(KD)之前和之后。
方法:我们对一名GLUT-1DS患者和27名健康对照者进行了微状态分析。进行了系统的文献综述和荟萃分析。我们比较了患者与健康对照组的参数以及文献中的合并发现。
结果:患者的病程明显较短,并且发生率比健康对照组更长,并且纳入了审查的结果。经过10个月的KD,患者的微状态持续时间从53.05ms增加,57.17ms,61.80ms,49.49ms到60.53ms,63.27ms,71.11ms,和66.55ms。发生率从4.0774Hz变化,4.9462Hz,4.8006Hz,和4.0579Hz至3.3354Hz,3.7893Hz,3.5956Hz,和4.1672Hz。在健康的控制中,微状态A类的持续时间,B,C,D为61.86ms,63.58ms,70.57ms,和72.00ms,分别。
结论:我们的研究结果表明,脑电图微状态可能是监测KD影响的有希望的生物标志物。KD的施用可以标准化时间参数的功能失调模式。
OBJECTIVE: The aim of the study is to analyze
microstate patterns in GLUT1-DS, both before and after the ketogenic diet (KD).
METHODS: We conducted
microstate analysis of a patient with GLUT-1 DS and 27 healthy controls. A systematic literature review and meta-analysis was done. We compared the parameters of the patients with those of healthy controls and the incorporating findings in literature.
RESULTS: The durations of the patient were notably shorter, and the occurrence rates were longer than those of healthy controls and incorporating findings from the review. After 10 months of KD, the patient\'s
microstate durations exhibited an increase from 53.05 ms, 57.17 ms, 61.80 ms, and 49.49 ms to 60.53 ms, 63.27 ms, 71.11 ms, and 66.55 ms. The occurrence rates changed from 4.0774 Hz, 4.9462 Hz, 4.8006 Hz, and 4.0579 Hz to 3.3354 Hz, 3.7893 Hz, 3.5956 Hz, and 4.1672 Hz. In healthy controls, the durations of
microstate class A, B, C, and D were 61.86 ms, 63.58 ms, 70.57 ms, and 72.00 ms, respectively.
CONCLUSIONS: Our findings suggest EEG microstates may be a promising biomarker for monitoring the effect of KD. Administration of KD may normalize the dysfunctional patterns of temporal parameters.