{Reference Type}: Journal Article
{Title}: EEG microstates in epilepsy with and without cognitive dysfunction: Alteration in intrinsic brain activity.
{Author}: Fang S;Zhu C;Zhang J;Wu L;Zhang Y;Huang H;Lin W;
{Journal}: Epilepsy Behav
{Volume}: 154
{Issue}: 0
{Year}: 2024 May 20
{Factor}: 3.337
{DOI}: 10.1016/j.yebeh.2024.109729
{Abstract}: <B>OBJECTIVE: </B>This study aims to investigate the difference between epilepsy comorbid with and without cognitive dysfunction.<BR><B>METHODS: </B>Participants were classified into patients with epilepsy comorbid cognitive dysfunction (PCCD) and patients with epilepsy without comorbid cognitive dysfunction (nPCCD). Microstate analysis was applied based on 20-channel electroencephalography (EEG) to detect the dynamic changes in the whole brain. The coverage, occurrence per second, duration, and transition probability were calculated.<BR><B>RESULTS: </B>The occurrence per second and the coverage of microstate B in the PCCD group were higher than that of the nPCCD group. Coverage in microstate D was lower in the PCCD group than in the nPCCD group. In addition, the PCCD group has a higher probability of A to B and B to A transitions and a lower probability of A to D and D to A transitions.<BR><B>CONCLUSIONS: </B>Our research scrutinizes the disparities observed within EEG microstates among epilepsy patients both with and without comorbid cognitive dysfunction.<BR><B>CONCLUSIONS: </B>EEG microstate analysis offers a novel metric for assessing neuropsychiatric disorders and supplies evidence for investigating the mechanisms and the dynamic change of epilepsy comorbid cognitive dysfunction.