■糖尿病肾病(DKD)是终末期肾病的主要原因。Metrnl是在肾脏疾病中起重要作用的分泌蛋白。这项研究的目的是探讨DKD相关因素以及血清Metrnl水平与DKD严重程度之间的相关性。
■96例2型糖尿病(T2DM)患者和45例DKD患者纳入研究。同时测量一系列参数,包括腰臀比(WHR),体重指数(BMI),尿白蛋白/肌酐比值(UACR),单核细胞-淋巴细胞比率(MLR),白蛋白/球蛋白(A/G),肝肾功能,血脂谱,胰岛函数,和其他人。随后,确定DKD的相关因素及预测意义。评价DKD相关因素及血清Metrnl水平与DKD的相关性。
■疾病的持续时间(OR:1.12,95%CI:1.01-1.24,P=0.031),高血压(OR:4.86,95%CI:1.16-20.49,P=0.031),空腹血糖(OR:1.23,95%CI:1.03-1.48,P=0.025),WHR(OR:2.53,95%CI:1.03-6.22,P=0.044),MLR(OR:1.91,95%CI:1.18~3.08,P=0.008)是DKD的独立危险因素(P<0.05)。相反,A/G(OR:0.13,95%CI:0.02-0.76,P=0.024)和Metrnl(OR:0.99,95%CI:0.98-1.00,P=0.001)已被确定为DKD的保护因素。此外,Metrnl水平与DKD严重程度呈负相关(rs=-0.447,P<0.001)。Metrnl对DKD的诊断准确性的接收器工作特征(ROC)曲线下面积为0.765(95%CI:0.686-0.844)。
■疾病的持续时间,高血压,空腹血糖,WHR,和MLR是DKD的主要危险因素。Metrnl和A/G是DKD的保护因子。血清Metrnl浓度与DKD严重程度成反比。
UNASSIGNED: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease.
Metrnl is a secreted protein that plays an important role in kidney disease. The aim of this study was to investigate DKD-related factors and the correlation between serum
Metrnl levels and the severity of DKD.
UNASSIGNED: Ninety-six type 2 diabetes mellitus (T2DM) patients and 45 DKD patients were included in the study. A range of parameters were measured simultaneously, including waist-to-hip ratio (WHR), body mass index (BMI), urinary albumin/creatinine ratio (UACR), monocyte-lymphocyte ratio (MLR), albumin/globulin (A/G), liver and kidney function, blood lipid profile, islet function, and others. Subsequently, the related factors and predictive significance of DKD were identified. The correlation between the relevant factors of DKD and serum
Metrnl levels with DKD was evaluated.
UNASSIGNED: The duration of the disease (OR: 1.12, 95% CI: 1.01-1.24, P=0.031), hypertension (OR: 4.86, 95% CI: 1.16-20.49, P=0.031), fasting blood glucose (OR: 1.23, 95% CI: 1.03-1.48, P=0.025), WHR (OR: 2.53, 95% CI: 1.03-6.22, P=0.044), and MLR (OR: 1.91, 95% CI: 1.18-3.08, P=0.008) are independent risk factors for DKD (P < 0.05). Conversely, A/G (OR: 0.13, 95% CI: 0.02-0.76, P=0.024) and Metrnl (OR: 0.99, 95% CI: 0.98-1.00, P=0.001) have been identified as protective factors against DKD. Furthermore, the level of Metrnl was negatively correlated with the severity of DKD (rs=-0.447, P<0.001). The area under receiver operating characteristic (ROC) curves for the diagnostic accuracy of Metrnl for DKD is 0.765 (95% CI: 0.686-0.844).
UNASSIGNED: The duration of the disease, hypertension, fasting blood glucose, WHR, and MLR are major risk factors for DKD.
Metrnl and A/G are protective factors for DKD. Serum
Metrnl concentrations are inversely correlated with DKD severity.