■探索导致老年患者意识丧失的环丙泊酚的中位有效剂量,并研究虚弱如何影响老年患者的环丙泊酚的ED50。
■共有26名非虚弱患者和28名虚弱患者,年龄在65-78岁之间,选择BMI范围为15至28kg/m2,并分类为ASAII级或III级。根据虚弱将患者分为两组:非虚弱患者(CFS<4),虚弱患者(CFS≥4)。老年非虚弱患者的初始剂量为0.3mg/kg,老年虚弱患者的初始剂量为0.25mg/kg,使用上下狄克逊方法,下一位患者的剂量取决于前一位患者的反应。人口统计信息,心率(HR),氧饱和度(SpO2),平均血压(MBP),每30秒记录一次脑电双频指数(BIS),从开始给药开始,持续到给药后3分钟。此外,诱导期间的环丙泊酚总剂量,低血压的发生,心动过缓,呼吸抑制,记录注射疼痛。
■计算的顺丙泊酚引起的意识丧失的ED50(95%置信区间[CI])和ED95(95%CI)值如下:老年非虚弱患者的0.267mg/kg(95%CI0.250-0.284)和0.301mg/kg(95%CI0.284-0.97);老年非虚弱患者的0.263mg/kg(95%CI0.244)0.281重要的是,没有患者报告静脉注射疼痛,低血压需要治疗,或经历了严重的心动过缓。
■老年患者的虚弱对麻醉诱导用顺丙泊酚的中位有效剂量没有显著影响。我们的发现表明,麻醉师可能会放弃剂量调整的必要性时,服用顺丙泊酚麻醉诱导老年虚弱患者。
UNASSIGNED: Explore the median effective dose of ciprofol for inducing loss of consciousness in elderly patients and investigate how frailty influences the ED50 of ciprofol in elderly patients.
UNASSIGNED: A total of 26 non-frail patients and 28 frail patients aged 65-78 years, with BMI ranging from 15 to 28 kg/m2, and classified as ASA grade II or III were selected. Patients were divided into two groups according to frailty: non-frail patients (CFS<4), frail patients (CFS≥4). With an initial dose of 0.3 mg/kg for elderly non-frail patients and 0.25 mg/kg for elderly frail patients, using the up-and-down Dixon method, and the next patient\'s dose was dependent on the previous patient\'s response. Demographic information, heart rate (HR), oxygen saturation (SpO2), mean blood pressure (MBP), and bispectral index (BIS) were recorded every 30 seconds, starting from the initiation of drug administration and continuing up to 3 minutes post-administration. Additionally, the total ciprofol dosage during induction, occurrences of hypotension, bradycardia, respiratory depression, and injection pain were recorded.
UNASSIGNED: The calculated ED50 (95% confidence interval [CI]) and ED95 (95% CI) values for ciprofol-induced loss of consciousness were as follows: 0.267 mg/kg (95% CI 0.250-0.284) and 0.301 mg/kg (95% CI 0.284-0.397) for elderly non-frail patients; and 0.263 mg/kg (95% CI 0.244-0.281) and 0.302 mg/kg (95% CI 0.283-0.412) for elderly frail patients. Importantly, no patients reported intravenous injection pain, required treatment for hypotension, or experienced significant bradycardia.
UNASSIGNED: Frailty among elderly patients does not exert a notable impact on the median effective dose of ciprofol for anesthesia induction. Our findings suggest that anesthesiologists may forego the necessity of dosage adjustments when administering ciprofol for anesthesia induction in elderly frail patients.