UNASSIGNED: A prospective sequential allocation study was conducted in children aged 1-60 months divided into Group A (1-18 months) and Group B (18-60 months). Children were administered dexmedetomidine intranasally as premedication. Sedation was assessed using the modified Observer Assessment of Alertness and Sedation Scale until induction. Successful mask acceptance was defined as a cooperative or asleep child during inhalational induction. The starting dose of dexmedetomidine was 1 µg/kg. The next dose varied by 0.2 µg/kg depending on the outcome of this case. According to the Dixon up-and-down method, the mean of midpoints of the failure-success sequence was calculated to obtain the ED50 values.
UNASSIGNED: The ED50 of intranasal dexmedetomidine for satisfactory mask acceptance was 0.7 µg/kg (95% confidence interval [CI]: 0.54-0.86) in Group A (n = 23) and 0.96 µg/kg (95% CI: 0.83-1.08) in Group B (n = 25) (P = 0.020). The mean (standard deviation) duration of anaesthesia was 33.5 (14.9) minutes in group A versus 23.5 (8.48) minutes in Group B (P = 0.007).
UNASSIGNED: ED50 was lower in children younger than 18 months than in older children. There was no difference in the time to discharge from the post-anaesthesia care unit despite the procedure being longer in smaller children.
■在1-60个月的儿童中进行了一项前瞻性顺序分配研究,分为A组(1-18个月)和B组(18-60个月)。儿童鼻内给予右美托咪定作为术前用药。使用改良的观察者警惕性评估和镇静量表评估镇静直至诱导。成功接受面罩被定义为吸入诱导期间合作或睡着的孩子。右美托咪定的起始剂量为1µg/kg。根据这种情况的结果,下一次剂量变化0.2µg/kg。根据狄克逊上下法,计算失败-成功序列中点的平均值以获得ED50值.
■在A组(n=23)中,鼻内右美托咪定的ED50为0.7µg/kg(95%置信区间[CI]:0.54-0.86),在B组(n=25)中为0.96µg/kg(95%CI:0.83-1.08)(P=0.020)。A组的平均麻醉时间(标准差)为33.5(14.9)分钟,B组为23.5(8.48)分钟(P=0.007)。
■18个月以下儿童的ED50低于年龄较大的儿童。尽管较小的儿童手术时间更长,但从麻醉后护理室出院的时间没有差异。