PDF(Pubmed)
Abstract：
UNASSIGNED: Inhalational technique is used to induce anaesthesia in children without intravenous access. We aimed to determine the median effective dose (ED50) of intranasal dexmedetomidine to ensure satisfactory mask acceptance during inhalation induction in children with retinoblastoma undergoing examination under anaesthesia.
UNASSIGNED: A prospective sequential allocation study was conducted in children aged 1-60 months divided into Group A (1-18 months) and Group B (18-60 months). Children were administered dexmedetomidine intranasally as premedication. Sedation was assessed using the modified Observer Assessment of Alertness and Sedation Scale until induction. Successful mask acceptance was defined as a cooperative or asleep child during inhalational induction. The starting dose of dexmedetomidine was 1 µg/kg. The next dose varied by 0.2 µg/kg depending on the outcome of this case. According to the Dixon up-and-down method, the mean of midpoints of the failure-success sequence was calculated to obtain the ED50 values.
UNASSIGNED: The ED50 of intranasal dexmedetomidine for satisfactory mask acceptance was 0.7 µg/kg (95% confidence interval [CI]: 0.54-0.86) in Group A (n = 23) and 0.96 µg/kg (95% CI: 0.83-1.08) in Group B (n = 25) (P = 0.020). The mean (standard deviation) duration of anaesthesia was 33.5 (14.9) minutes in group A versus 23.5 (8.48) minutes in Group B (P = 0.007).
UNASSIGNED: ED50 was lower in children younger than 18 months than in older children. There was no difference in the time to discharge from the post-anaesthesia care unit despite the procedure being longer in smaller children.
UNASSIGNED: A prospective sequential allocation study was conducted in children aged 1-60 months divided into Group A (1-18 months) and Group B (18-60 months). Children were administered dexmedetomidine intranasally as premedication. Sedation was assessed using the modified Observer Assessment of Alertness and Sedation Scale until induction. Successful mask acceptance was defined as a cooperative or asleep child during inhalational induction. The starting dose of dexmedetomidine was 1 µg/kg. The next dose varied by 0.2 µg/kg depending on the outcome of this case. According to the Dixon up-and-down method, the mean of midpoints of the failure-success sequence was calculated to obtain the ED50 values.
UNASSIGNED: The ED50 of intranasal dexmedetomidine for satisfactory mask acceptance was 0.7 µg/kg (95% confidence interval [CI]: 0.54-0.86) in Group A (n = 23) and 0.96 µg/kg (95% CI: 0.83-1.08) in Group B (n = 25) (P = 0.020). The mean (standard deviation) duration of anaesthesia was 33.5 (14.9) minutes in group A versus 23.5 (8.48) minutes in Group B (P = 0.007).
UNASSIGNED: ED50 was lower in children younger than 18 months than in older children. There was no difference in the time to discharge from the post-anaesthesia care unit despite the procedure being longer in smaller children.
摘要：
■吸入技术用于在没有静脉通路的儿童中诱导麻醉。我们旨在确定鼻内右美托咪定的中位有效剂量（ED50），以确保在麻醉下接受检查的视网膜母细胞瘤患儿在吸入诱导期间满意的面罩接受度。
■在1-60个月的儿童中进行了一项前瞻性顺序分配研究，分为A组（1-18个月）和B组（18-60个月）。儿童鼻内给予右美托咪定作为术前用药。使用改良的观察者警惕性评估和镇静量表评估镇静直至诱导。成功接受面罩被定义为吸入诱导期间合作或睡着的孩子。右美托咪定的起始剂量为1µg/kg。根据这种情况的结果，下一次剂量变化0.2µg/kg。根据狄克逊上下法,计算失败-成功序列中点的平均值以获得ED50值.
■在A组（n=23）中，鼻内右美托咪定的ED50为0.7µg/kg（95％置信区间[CI]：0.54-0.86），在B组（n=25）中为0.96µg/kg（95％CI：0.83-1.08）（P=0.020）。A组的平均麻醉时间（标准差）为33.5（14.9）分钟，B组为23.5（8.48）分钟（P=0.007）。
■18个月以下儿童的ED50低于年龄较大的儿童。尽管较小的儿童手术时间更长，但从麻醉后护理室出院的时间没有差异。
■在1-60个月的儿童中进行了一项前瞻性顺序分配研究，分为A组（1-18个月）和B组（18-60个月）。儿童鼻内给予右美托咪定作为术前用药。使用改良的观察者警惕性评估和镇静量表评估镇静直至诱导。成功接受面罩被定义为吸入诱导期间合作或睡着的孩子。右美托咪定的起始剂量为1µg/kg。根据这种情况的结果，下一次剂量变化0.2µg/kg。根据狄克逊上下法,计算失败-成功序列中点的平均值以获得ED50值.
■在A组（n=23）中，鼻内右美托咪定的ED50为0.7µg/kg（95％置信区间[CI]：0.54-0.86），在B组（n=25）中为0.96µg/kg（95％CI：0.83-1.08）（P=0.020）。A组的平均麻醉时间（标准差）为33.5（14.9）分钟，B组为23.5（8.48）分钟（P=0.007）。
■18个月以下儿童的ED50低于年龄较大的儿童。尽管较小的儿童手术时间更长，但从麻醉后护理室出院的时间没有差异。
