背景:关于患有乳腺肿瘤的母犬维生素D状况的信息很少。
目的:为了确定是否在患有乳腺肿瘤的母犬中发现低血浆维生素D浓度。
方法:85名患有乳腺肿瘤的客户拥有的母狗(n=21名良性,n=64个恶性)和39个年龄匹配的健康母狗。
方法:病例对照研究。等离子体离子化和总钙,磷,镁,尿素,肌酐,白蛋白,总蛋白质,丙氨酸氨基转移酶,碱性磷酸酶,甲状旁腺激素(PTH),骨化三醇(1,25-二羟基维生素D),在临床诊断时和任何治疗前,测量所有母犬的25-羟基维生素D浓度。进行统计分析以比较组间变量(对照组,良性,和恶性)。
结果:当恶性乳腺肿瘤母犬的血浆25-羟基维生素D浓度(148.9[59.9]ng/mL)和良性乳腺肿瘤(150.1[122.3]ng/mL)与对照组(129.9[54.5]ng/mL)相比时,没有发现显着差异。甲状旁腺激素在恶性母犬中显著增高(19.9[20.5]pg/mL),良性乳腺肿瘤(14.6[14.9]pg/mL)与对照组(7.5[7.5]pg/mL;P<0.01)。只有乳腺肿瘤的存在(P<.01)和年龄(P=.04;调整后的R2=.22)对预测PTH有显著意义。
结论:患有乳腺肿瘤的母犬25-羟基维生素D浓度不高,因此补充维生素D对预防母犬乳腺肿瘤不太可能有用。
BACKGROUND: Little information exists about vitamin D status in bitches with mammary tumors.
OBJECTIVE: To determine whether low plasma vitamin D concentrations are found in bitches with mammary tumors.
METHODS: Eighty-five client-owned bitches with mammary tumors (n = 21 benign, n = 64 malignant) and 39 age-matched healthy bitches.
METHODS: Case-control study. Plasma ionized and total calcium, phosphorus, magnesium, urea, creatinine, albumin, total proteins, alanine aminotransferase, alkaline phosphatase, parathyroid hormone (PTH), calcitriol (1,25-dihydroxyvitamin D), and 25-hydroxyvitamin D concentrations were measured in all bitches at the time of clinical diagnosis and before any treatments. Statistical analysis was performed to compare variables among groups (control, benign, and malignant).
RESULTS: No significant differences were found when plasma 25-hydroxyvitamin D concentrations in bitches with malignant (148.9 [59.9] ng/mL) and benign mammary tumors (150.1 [122.3] ng/mL) were compared with control group (129.9 [54.5] ng/mL). Parathyroid hormone was significantly higher in bitches with malignant (19.9 [20.5] pg/mL), and benign mammary tumors (14.6 [14.9] pg/mL) compared with control group (7.5 [7.5] pg/mL; P < .01). Only the presence of mammary tumors (P < .01) and age (P = .04; adjusted R2 = .22) was significant in predicting PTH.
CONCLUSIONS: Bitches with mammary tumors do not have low 25-hydroxyvitamin D concentrations thus vitamin D supplementation is unlikely to be useful for prevention of mammary tumors in bitches.