Abstract：
OBJECTIVE: In this study, we aimed to assess the new trends in characteristics, molecular subtypes, and imaging findings of breast cancer in very young women.
METHODS: We retrospectively reviewed the database of a primary breast cancer referral center in southern Iran in 342 cases of 30-year-old or younger women from 2001 to 2020. Pathologic data, including nuclear subtype and grade, tumor stage, presence of in situ cancer, imaging data including lesion type in mammogram and ultrasound, and treatment data were recorded. Descriptive statistics were applied. Differences between categorical values between groups were compared using Pearson\'s Chi-square test.
RESULTS: The mean age was 27.89 years. The tumor type was invasive ductal carcinoma in 82 % of cases. Fourteen patients (4.4 %) had only in situ cancer, and 170 patients had in situ components (49.7 %). Molecular subtypes were available in 278 patients, including 117 (42.1 %) Luminal A, 64 (23.0 %) Luminal B, 58 (20.9 %) triple negative, and 39 (14 %) HER2 Enriched. In those with mammograms available, 63 (30.1 %) had no findings, 53 (25.3 %) had mass, 27 (12.9 %) had asymmetry, whether focal or global, 21 (10 %) had microcalcifications solely, and 45 (21.5 %) had more than one finding. Microcalcifications were significantly more common in Luminal cancers than HER2 and triple-negative cancers (p = 0.041).
CONCLUSIONS: Our study shows the most common subtype to be Luminal A cancer, with 74 % of the tumors being larger than 2 cm at the time of diagnosis. Irregular masses with non-circumscribed margins were the most common imaging findings.
METHODS: We retrospectively reviewed the database of a primary breast cancer referral center in southern Iran in 342 cases of 30-year-old or younger women from 2001 to 2020. Pathologic data, including nuclear subtype and grade, tumor stage, presence of in situ cancer, imaging data including lesion type in mammogram and ultrasound, and treatment data were recorded. Descriptive statistics were applied. Differences between categorical values between groups were compared using Pearson\'s Chi-square test.
RESULTS: The mean age was 27.89 years. The tumor type was invasive ductal carcinoma in 82 % of cases. Fourteen patients (4.4 %) had only in situ cancer, and 170 patients had in situ components (49.7 %). Molecular subtypes were available in 278 patients, including 117 (42.1 %) Luminal A, 64 (23.0 %) Luminal B, 58 (20.9 %) triple negative, and 39 (14 %) HER2 Enriched. In those with mammograms available, 63 (30.1 %) had no findings, 53 (25.3 %) had mass, 27 (12.9 %) had asymmetry, whether focal or global, 21 (10 %) had microcalcifications solely, and 45 (21.5 %) had more than one finding. Microcalcifications were significantly more common in Luminal cancers than HER2 and triple-negative cancers (p = 0.041).
CONCLUSIONS: Our study shows the most common subtype to be Luminal A cancer, with 74 % of the tumors being larger than 2 cm at the time of diagnosis. Irregular masses with non-circumscribed margins were the most common imaging findings.
摘要：
目的：在本研究中，我们旨在评估特征的新趋势，分子亚型,和年轻女性乳腺癌的影像学发现。
方法：我们回顾性回顾了2001年至2020年伊朗南部一个原发性乳腺癌转诊中心的342例30岁或更年轻女性的数据库。病理资料,包括核亚型和级别，肿瘤分期,原位癌的存在，影像学数据，包括乳房X线照片和超声检查中的病变类型，并记录治疗数据。采用描述性统计。使用Pearson卡方检验比较组间分类值之间的差异。
结果：平均年龄为27.89岁。82％的病例肿瘤类型为浸润性导管癌。14例患者（4.4%）只有原位癌，170例患者有原位成分(49.7%)。278例患者有分子亚型，包括117（42.1％）管腔A，64（23.0％）管腔B，58（20.9%）三负，和39（14％）HER2富集。在那些有乳房X光照片的人中，63（30.1%）没有发现，53（25.3%）有质量，27（12.9%）存在不对称性，无论是焦点还是全球，21（10%）仅有微钙化，45人(21.5%)有一个以上的发现。微钙化在管腔癌中比HER2和三阴性癌中明显更常见（p=0.041）。
结论：我们的研究表明，最常见的亚型是管腔A癌，74％的肿瘤在诊断时大于2厘米。边缘无界限的不规则肿块是最常见的影像学发现。
方法：我们回顾性回顾了2001年至2020年伊朗南部一个原发性乳腺癌转诊中心的342例30岁或更年轻女性的数据库。病理资料,包括核亚型和级别，肿瘤分期,原位癌的存在，影像学数据，包括乳房X线照片和超声检查中的病变类型，并记录治疗数据。采用描述性统计。使用Pearson卡方检验比较组间分类值之间的差异。
结果：平均年龄为27.89岁。82％的病例肿瘤类型为浸润性导管癌。14例患者（4.4%）只有原位癌，170例患者有原位成分(49.7%)。278例患者有分子亚型，包括117（42.1％）管腔A，64（23.0％）管腔B，58（20.9%）三负，和39（14％）HER2富集。在那些有乳房X光照片的人中，63（30.1%）没有发现，53（25.3%）有质量，27（12.9%）存在不对称性，无论是焦点还是全球，21（10%）仅有微钙化，45人(21.5%)有一个以上的发现。微钙化在管腔癌中比HER2和三阴性癌中明显更常见（p=0.041）。
结论：我们的研究表明，最常见的亚型是管腔A癌，74％的肿瘤在诊断时大于2厘米。边缘无界限的不规则肿块是最常见的影像学发现。
