在与精液质量和男性生育能力有关的众多因素中,精浆细胞因子的测定为男性不育相关因素的研究提供了一个有希望的方向。白细胞介素:IL-1α,-1β,-2,-4,-6,-8,-10,-12p40,-12p70,-18,IFNγ,和GM-CSF,总氧化剂(TOS)和抗氧化剂(TAS)状态,在精浆和血液血清中同时检查-(n=32),哮喘-(n=33),和少弱精子症(n=29)不育男性和正常精子症可育男性(n=20)。我们的研究表明,在所有研究组中,血清和精浆的细胞因子组成不同,精浆GM-CSF的浓度更高,IFNγ,IL-1α,IL-4、IL-6和IL-8与它们的血清水平相比更低的IL-18和TOS。GM-CSF的精浆浓度,IFNγ,IL-1α,-4和-6在可育和不育以及畸形精子症之间存在显着差异,弱精子症,和少弱精子症组。说明不育男性精浆中不同浓度细胞因子的原因,以及它们与精液参数和氧化状态的关系,可能是寻找直接影响男性生殖器官细胞和组织的新治疗靶点的一个有希望的方向。
Among the many factors with a proven relation to semen quality and male fertility, the determination of seminal plasma cytokines provides a promising direction for research into the identification of factors connected with male infertility. The interleukins: IL-1α, -1β, -2, -4, -6, -8, -10, -12p40, -12p70, -18, IFNγ, and GM-CSF, total oxidant (TOS) and antioxidant (TAS) status, were simultaneously examined in seminal plasmas and blood sera in terato- (n = 32), asthenoterato- (n = 33), and oligoasthenoteratozoospermic (n = 29) infertile men and in normozoospermic fertile men (n = 20). Our research shows different cytokine composition of the sera and seminal plasmas in all studied groups, along with much higher concentrations of seminal plasma GM-CSF, IFNγ, IL-1α, IL-4, IL-6, and IL-8 and lower IL-18 and TOS in the comparison to their sera levels. The seminal plasma concentrations of GM-CSF, IFNγ, IL-1α, -4, and -6 differ significantly between fertile and infertile as well as between teratozoospermic, asthenoteratozoospermic, and oligoasthenoteratozoospermic groups. The indication of the cause of different concentrations of cytokines in seminal plasmas of infertile men, and their associations with semen parameters and oxidative status, may be a promising direction for the search for new therapeutic targets that would directly affect the cells and tissues of male reproductive organs.