背景:这项研究的目的是确定黄斑厚度和相关因素的5年变化。
方法:数据来自Shahroud眼队列研究的第二阶段(2014年)和第三阶段(2019年)。检查包括测量未矫正和最佳矫正视力,非睫状肌麻痹自屈光,裂隙灯生物显微镜,和Funduscopy。参与者接受了CirrusHD-OCT4000(CarlZeissMeditec,都柏林,CA).
方法:
结果:中央和总体黄斑厚度的5年变化(95%置信区间)为-3.48±8.16μ(-3.92,-3.03)和-0.79±4.06μ(-1.03,-0.54),分别。中央子场厚度5年变化的中位数和IQR分别为-3和10,尽管它们在总体黄斑厚度中分别为0和5,分别。多元回归模型显示,随着年龄的增长,黄斑中心厚度(CMT)呈U形减少。女性与男性相比,CMT的5年变化显着降低β=-1.55;(-2.78,-0.32),吸烟者与不吸烟者相比,β=-1.92;(-3.55,-0.28)。此外,较高的体重指数β=-0.12;(-0.22,-0.02)和基线时的CMT=-0.08;(-0.10,-0.06)与较低的CMT变化显著相关.总体黄斑厚度的平均5年变化显示出随年龄的非线性下降,女性β=0.93;(0.4,1.43)。这些变化与基线的前房深度β=0.87;(0.10,1.64)直接相关。
结论:黄斑厚度在5年后略有下降;然而,这种变化在临床上并不显著.年龄、性别和屈光不正等人口统计学因素与黄斑厚度变化显著相关。
BACKGROUND: The aim of this study is to determine the 5-year changes in macular thickness and related factors.
METHODS: Data were from the second (2014) and third (2019) phases of the Shahroud Eye Cohort Study. Examinations included measurement of uncorrected and best-corrected visual acuity, non-cycloplegic autorefraction, slit-lamp biomicroscopy, and funduscopy. Participants underwent Cirrus HD-OCT 4000 (Carl Zeiss Meditec, Dublin, CA).
METHODS: RESULTS: The 5-year changes (95% confidence interval) of central and overall macular thicknesses were - 3.48 ± 8.16 μ (-3.92, -3.03) and - 0.79 ± 4.06 μ (-1.03, -0.54), respectively. The median and IQR of 5-year changes in the central subfield thickness were -3 and 10, although they were 0 and 5 in the overall macular thickness, respectively. Multiple regression model showed the central macular thickness (CMT) decreased with a U-shape pattern with increasing age. The 5-year changes in CMT were significantly lower in females compared to males β = -1.55; (-2.78, -0.32) and in smokers compared to non-smokers β = -1.92; (-3.55, -0.28). Moreover, higher body mass index β = -0.12; (-0.22, -0.02) and CMT at baseline β = -0.08; (-0.10, -0.06) were significantly associated with lower CMT changes. The average 5-year changes in overall macular thickness showed a non-linear decrease with age and was significantly higher in females β = 0.93; (0.4, 1.43). These changes were directly related to the anterior chamber depth β = 0.87; (0.10, 1.64) in the baseline.
CONCLUSIONS: The macular thickness decreased slightly after 5 years; however, this change is not clinically significant. Demographic factors such as age and sex and refractive errors were significantly related to macular thickness changes.