目的:本初步研究的目的是评估富血小板纤维蛋白(PRF)根尖屏障放置MTA治疗根尖周病变和开放牙尖的有效性。
方法:在本试验研究中,共纳入28例开放性根尖周炎患者的30颗牙齿,并分为两组。在PRF组中(13例患者中有14颗牙齿),使用PRF作为根尖基质进行非手术牙髓治疗,之后,MTA的顶端插头被创建。对于非PRF组(14例患者中的14颗牙齿),非手术牙髓治疗仅使用MTA治疗根尖塞,无进一步根尖周干预.在1、3、6和9个月的定期随访后,临床发现和根尖周数字X线片用于评估愈合进展。测量了根尖周病变的水平尺寸,并记录每次尺寸的变化。弗里德曼测试,Dunn-Bonferroni事后更正,采用Mann-WhitneyU检验进行统计分析,以P<0.05作为确定统计学意义的阈值。
结果:本试验研究中两组患者1个月后均无临床症状,定期预约后,根尖周病变显着减少。PRF组在治疗后第6个月和第9个月的病灶宽度明显小于非PRF组。
结论:PRF与MTA联合用于治疗具有开放根尖和根尖周炎的牙齿时,是一种有前途的根尖屏障基质。研究对象数量少和随访时间短限制了这些结果的普遍性。
背景:TCTR,TCTR20221109006。2022年11月9日注册-回顾性注册,https://www.thaiclinicaltrials.org/show/TCTR20221109006.
OBJECTIVE: The aim of the present pilot study was to assess the effectiveness of the platelet-rich fibrin (PRF) apical barrier for the placement of
MTA for the treatment of teeth with periapical lesions and open apices.
METHODS: A total of thirty teeth on twenty-eight patients with open apices and periapical periodontitis were enrolled and divided into two groups in the present pilot study. In the PRF group (fourteen teeth in thirteen patients), nonsurgical endodontic treatment was performed using PRF as an apical matrix, after which the apical plug of the
MTA was created. For the non-PRF group (fourteen teeth in fourteen patients), nonsurgical endodontic therapy was performed using only the
MTA for an apical plug with no further periapical intervention. Clinical findings and periapical digital radiographs were used for evaluating the healing progress after periodic follow-ups of 1, 3, 6, and 9 months. The horizontal dimension of the periapical lesion was gauged, and the changes in the dimensions were recorded each time. The Friedman test, Dunn-Bonferroni post hoc correction, and Mann-Whitney U test were used for statistical analysis, with P < 0.05 serving as the threshold for determining statistical significance.
RESULTS: All patients in both groups in the present pilot study had no clinical symptoms after 1 month, with a significant reduction in the periapical lesion after periodic appointments. The lesion width of the PRF group was significantly smaller than that of the non-PRF group in the sixth and ninth month after treatment.
CONCLUSIONS: PRF is a promising apical barrier matrix when combined with
MTA for the treatment of teeth with open apices and periapical periodontitis. Small number of study subjects and the short time of follow-up period limit the generalizability of these results.
BACKGROUND: TCTR, TCTR20221109006. Registered 09 November 2022 - Retrospectively registered, https://www.thaiclinicaltrials.org/show/TCTR20221109006 .