未经证实:原发性硬化性胆管炎(PSC)患者的病程可变且通常为进行性,与胆道和实质改变有关。这些变化通常通过磁共振成像(MRI)来评估,包括磁共振胰胆管造影(MRCP)的定性评估。我们的目的是研究新的客观定量MRCP指标与预后评分和患者预后的关系。
UASSIGNED:我们进行了一项回顾性研究,包括77例具有基线MRCP图像的大导管PSC个体,对其进行后处理以使用MRCP+™获得胆管的定量测量。参与者\'ANALI得分,通过振动控制的瞬时弹性成像,肝脏硬度,在基线时收集生化指标。无不良结局生存率测量为无失代偿期肝硬化,肝移植,或超过12年的肝脏相关死亡。通过Cox回归模型评估MRCP衍生指标的预后价值。
未经证实:在总共386名患者-年中,16例失代偿,2LTs,并记录5例肝脏相关死亡。在基线,约50%的患者被归类为有发生疾病并发症的风险.MRCP+度量,特别是那些描述胆管扩张的严重程度,与所有预后因素相关。单变量分析表明,代表管道直径的MRCP+指标,扩张,导管狭窄和/或扩张的百分比与生存率相关。在多变量调整分析中,中位导管直径与生存显著相关(风险比10.9,95%CI1.3-90.3).
未经证实:PSC患者的MRCP+指标与生化指标相关,弹性成像,和放射学预后评分,并预测无不良结局的生存。
未经批准:在这项研究中,我们在原发性硬化性胆管炎(PSC)患者中评估了由软件工具(MRCP+)自动提供的新型客观定量MRCP指标与预后评分和患者结局的相关性.我们观察到PSC患者的MRCP+指标与生化指标相关,弹性成像,和放射学预后评分,并预测无不良结局的生存。
UNASSIGNED: People with primary sclerosing cholangitis (PSC) have a variable and often progressive disease course that is associated with biliary and parenchymal changes. These changes are typically assessed by magnetic resonance imaging (MRI), including qualitative assessment of magnetic resonance cholangiopancreatography (MRCP). Our aim was to study the association of novel objective quantitative MRCP metrics with prognostic scores and patient outcomes.
UNASSIGNED: We performed a retrospective study including 77 individuals with large-duct PSC with baseline MRCP images, which were postprocessed to obtain quantitative measures of bile ducts using MRCP+™. The participants\' ANALI scores, liver stiffness by vibration-controlled transient elastography, and biochemical indices were collected at baseline. Adverse outcome-free survival was measured as the absence of decompensated cirrhosis, liver transplantation (LT), or liver-related death over a 12-year period. The prognostic value of MRCP+-derived metrics was assessed by Cox regression modelling.
UNASSIGNED: During a total of 386 patients-years, 16 cases of decompensation, 2 LTs, and 5 liver-related deaths were recorded. At baseline, around 50% of the patients were classified as being at risk of developing disease complications. MRCP+ metrics, particularly those describing the severity of bile duct dilatations, were correlated with all prognostic factors. Univariate analysis showed that MRCP+ metrics representing duct diameter, dilatations, and the percentage of ducts with strictures and/or dilatations were associated with survival. In a multivariable-adjusted analysis, the median duct diameter was significantly associated with survival (hazard ratio 10.9, 95% CI 1.3-90.3).
UNASSIGNED: MRCP+ metrics in people with PSC correlate with biochemical, elastographic, and radiological prognostic scores and are predictive of adverse outcome-free survival.
UNASSIGNED: In this study, we assessed in people with primary sclerosing cholangitis (PSC) the association of novel objective quantitative MRCP metrics automatically provided by a software tool (MRCP+) with prognostic scores and patient outcomes. We observed that MRCP+ metrics in people with PSC correlate with biochemical, elastographic, and radiological prognostic scores and are predictive of adverse outcome-free survival.