■肠道菌群与血液恶性肿瘤之间的关系引起了相当大的关注。随着研究的进展,越来越清楚的是,肠道菌群的组成可能影响血液系统恶性肿瘤的发生和进展.然而,我们对这种联系的理解仍然有限。
■在我们的研究中,我们根据门的信息将肠道菌群分为五组,类,订单,家庭,和属水平。随后,我们从IEUOpenGWAS项目获得了与常见血液系统恶性肿瘤相关的数据.然后,我们采用双向孟德尔随机化(MR)方法来确定肠道微生物群与血液恶性肿瘤之间是否存在因果关系。此外,我们进行了双向MR分析,以确定这种因果关系的方向性.
■通过正向和反向MR分析,我们发现淋巴样白血病的风险与蓝藻门的丰度显著相关,甲烷杆菌订单,甲烷细菌类,Peptococaceae,甲烷细菌科,和落叶松科属UCG010,甲氧菌,肠杆菌组,还有Butyrivibrio.骨髓性白血病的风险与放线菌门的丰度显着相关,Firmicutes门,订购双歧杆菌,订购梭菌,放线菌类,类γ变形杆菌,类梭菌,双歧杆菌科,和镰刀菌属,Hallii真杆菌组,Blautia,Collinsella,卷羊乳球菌群,和双歧杆菌.霍奇金淋巴瘤的风险与vadinBB60家族梭菌的丰度显著相关,肽球菌属,和Ruminocycaceae属UCG010。恶性浆细胞肿瘤的风险与Romboutsia属和Eubacterium复发组的丰度显着相关。弥漫性大B细胞淋巴瘤的风险与Eresponatoclostridium和Eubacteriumcoprostanolidgenes组的丰度显着相关。成熟T/NK细胞淋巴瘤的风险与Verrucombicrobia门的丰度显着相关,Ruminococycaceae属UCG013,真杆菌属。最后,骨髓增殖性肿瘤的风险与共球菌3属和嗜真杆菌组的丰度显著相关.
■我们的研究为肠道菌群与血液系统恶性肿瘤之间的因果关系提供了新的证据。为预防和治疗这些肿瘤提供了新的见解和方法。
UNASSIGNED: The relationship between gut microbiota and hematologic malignancies has attracted considerable attention. As research progresses, it has become increasingly clear that the composition of gut microbiota may influence the onset and progression of hematologic malignancies. However, our understanding of this association remains limited.
UNASSIGNED: In our study, we classified gut microbiota into five groups based on information at the phylum, class, order, family, and genus levels. Subsequently, we obtained data related to common hematologic malignancies from the IEU Open GWAS project. We then employed a bidirectional Mendelian Randomization (
MR) approach to determine whether there is a causal relationship between gut microbiota and hematologic malignancies. Additionally, we conducted bidirectional
MR analyses to ascertain the directionality of this causal relationship.
UNASSIGNED: Through forward and reverse
MR analyses, we found the risk of lymphoid leukemia was significantly associated with the abundance of phylum Cyanobacteria, order Methanobacteriales, class Methanobacteria, family Peptococcaceae, family Methanobacteriaceae, and genera Lachnospiraceae UCG010, Methanobrevibacter, Eubacterium brachy group, and Butyrivibrio. The risk of myeloid leukemia was significantly associated with the abundance of phylum Actinobacteria, phylum Firmicutes, order Bifidobacteriales, order Clostridiales, class Actinobacteria, class Gammaproteobacteria, class Clostridia, family Bifidobacteriaceae, and genera Fusicatenibacter, Eubacterium hallii group, Blautia, Collinsella, Ruminococcus gauvreauii group, and Bifidobacterium. The risk of Hodgkin lymphoma was significantly associated with the abundance of family Clostridiales vadinBB60 group, genus Peptococcus, and genus Ruminococcaceae UCG010. The risk of malignant plasma cell tumor was significantly associated with the abundance of genera Romboutsia and Eubacterium rectale group. The risk of diffuse large B-cell lymphoma was significantly associated with the abundance of genera Erysipelatoclostridium and Eubacterium coprostanoligenes group. The risk of mature T/NK cell lymphomas was significantly associated with the abundance of phylum Verrucomicrobia, genus Ruminococcaceae UCG013, genus Lachnoclostridium, and genus Eubacterium rectale group. Lastly, the risk of myeloproliferative neoplasms was significantly associated with the abundance of genus Coprococcus 3 and Eubacterium hallii group.
UNASSIGNED: Our study provided new evidence for the causal relationship between gut microbiota and hematologic malignancies, offering novel insights and approaches for the prevention and treatment of these tumors.