■慢性斑块型银屑病是一种慢性炎症性皮肤病。肥胖合并症,包括非酒精性脂肪肝,在慢性斑块型银屑病患者中非常普遍。最近,减肥一直是高度推荐的干预措施,以改善银屑病症状的严重程度,银屑病引起的慢性全身性炎症,银屑病相关心血管危险因素,生活质量,以及抗银屑病药物的疗效。这项研究旨在评估12周低热量饮食干预对天冬氨酸转氨酶的影响。银屑病严重程度(通过银屑病面积和严重程度指数-PASI评估),丙氨酸转氨酶,生活质量(通过皮肤科生活质量指数-DLQI评估),甘油三酯,腰围(WC),患有慢性斑块和非酒精性脂肪性肝病的I类肥胖男性的体重指数(BMI)。
■60名年龄≥18岁的I类肥胖、慢性斑块状银屑病和非酒精性脂肪肝患者被纳入研究。所有参与者被随机分配到两组中的一组:第一组为低热量饮食组(30名男性接受了免疫抑制药物,遵循低热量饮食,并通过每天15,000步的户外步行计划增加了他们的能量消耗,持续12周),第二个作为对照组(30名男性仅接受免疫抑制药物)。主要结果包括面积和严重程度指数的结果。重量,BMI,WC,实验室结果,如甘油三酯,肝酶(丙氨酸转氨酶和天冬氨酸转氨酶)以及DLQI被认为是次要结局.
■虽然对照组的测量变量没有显着改善,低热量饮食组的所有测量变量均有显著改善.
■本研究的结果证实,为期12周的低热量饮食干预可以控制BMI,增加牛皮癣对药物的反应,提高生活质量。饮食干预可显着控制慢性斑块型银屑病和非酒精性脂肪肝男性患者的肝酶(天冬氨酸和丙氨酸转氨酶)和甘油三酸酯升高。
UNASSIGNED: Chronic-plaque psoriasis is a chronic inflammatory dermatological disease. Obesity comorbidities, including non-alcoholic fatty liver disease, are highly prevalent in patients with chronic-plaque psoriasis. Recently, weight loss has been a highly recommended intervention to improve the severity of psoriatic symptoms, psoriasis-induced chronic systemic inflammation, psoriasis-associated cardiovascular risk factors, quality of life, and the efficacy of anti-psoriatic drugs. This study was designed to assess the effect of a 12-week low-calorie-diet intervention on aspartate transaminase, psoriasis severity (assessed via Psoriasis Area and Severity Index - PASI), alanine transaminase, quality of life (assessed via Dermatology Life Quality Index - DLQI), triglycerides, waist circumference (WC), and body mass index (BMI) in class I obese men with chronic-plaque and non-alcoholic fatty liver disease.
UNASSIGNED: Sixty men with age ≥ 18 years with class I obesity and with chronic plaque psoriasis and non-alcoholic fatty liver disease were included in the study. All participants were randomly assigned to one of two groups: the first group as the low-calorie-diet group (30 men received immunosuppressive drugs, followed a low-calorie diet, and increased their energy expenditure through a daily 15,000-step outdoor walking program for 12 weeks) and the second as the control group (30 men received immunosuppressive drugs only). The primary outcome consisted of the results of the area and severity index. Weight, BMI, WC, laboratory results such as triglycerides, liver enzymes (alanine transaminase and aspartate transaminase) as well as DLQI were considered as secondary outcomes.
UNASSIGNED: While no significant improvements were achieved in the measured variables of the control group, the low-calorie-diet group demonstrated significant improvement in all the measured variables.
UNASSIGNED: The results of the present study confirmed that 12-week low-calorie-diet intervention controls BMI, increases the response of psoriasis to pharmacological agents and improves the quality of life. Diet interventions significantly control the elevated hepatic enzymes (aspartate and alanine transaminases) and triglycerides in male patients with chronic-plaque psoriasis and non-alcoholic fatty liver disease.