■肌肉减少症会导致严重的个人,社会,和经济负担。肌少症的诊断很大程度上依赖于低骨骼肌质量(LSMM)的鉴定,它是脆弱的独立预测因子,残疾,老年人死亡风险增加。女性在生理上的骨骼肌质量比男性低,女性肌肉减少症似乎更受更年期的影响。他们的体内脂肪含量也比人类高,这增加了肌肉减少症肥胖的风险。在另一条战线上,人们还认识到,人类在很大程度上容易感染幽门螺杆菌(H.幽门螺杆菌)感染,全球患病率通常超过50%。然而,幽门螺杆菌感染和LSMM之间的相互关系仍未被研究.因此,我们的研究特别针对女性作为研究人群,并试图探索LSMM的几个危险因素.此外,我们深入研究了女性LSMM与幽门螺杆菌感染之间的潜在相关性,希望深入了解可能提高受肌少症影响的女性生活质量的潜在预防措施或治疗方案。
■我们在18岁以上接受体检的女性中进行了一项横断面研究。我们进行了13C尿素呼气试验(UBT)以诊断幽门螺杆菌感染,并进行了生物电阻抗分析(BIA)以评估LSMM。采用Logistic回归模型分析幽门螺杆菌感染与LSMM的相关性。
这项研究招募了1984名正在接受健康检查的中国女性。单变量逻辑回归分析未显示该女性人群中幽门螺杆菌感染与LSMM之间存在直接相关性(OR=1.149,95%CI0.904-1.459,p=0.257)。然而,将参与者分为基于年龄的亚组,在40岁或以上的女性中,幽门螺杆菌感染与LSMM之间存在明显的联系(OR=1.381,95CI1.032~1.848,p=0.030).调整包括年龄在内的变量后,BMI,TP,ALK,Cre,这种关系仍然具有统计学相关性(OR=1.514,95CI1.085-2.113,p=0.015).
40岁以上且目前感染幽门螺杆菌的女性患LSMM的风险增加。因此,建议对这组女性进行及时根除幽门螺杆菌的治疗,以减少LSMM的发生.
Sarcopenia can lead to significant personal, social, and economic burdens. The diagnosis of sarcopenia heavily relies on the identification of Low Skeletal Muscle Mass (LSMM), which is an independent predictor of frailty, disability, and increased risk of death among seniors. Women have physiologically lower levels of skeletal muscle mass than men, and female sarcopenia appears to be more influenced by menopause. They also tend to have higher body fat levels than man, which increases the risk of sarcopenia obesity. On another front, it\'s also recognized that humans are largely prone to Helicobacter pylori (H. pylori) infection, with global prevalence rates often surpassing 50%. Nevertheless, the interconnection between H. pylori infection and LSMM remains relatively unexplored. Hence, our study specifically targeted women as the research population and sought to explore several risk factors for LSMM. Additionally, we delved into the potential correlation between LSMM and H. pylori infection in women, hoping to gain insights into potential preventative measures or treatment options that may enhance the quality of life for women affected by sarcopenia.
We conducted a cross-sectional study among women aged over 18 years undergoing physical examination. We performed 13C-urea breath test (UBT) for diagnosis of H. pylori infection and Bioelectrical impedance analysis (BIA) for the assessment of LSMM. Logistic regression models were used to analyze the associations of H. pylori infection with LSMM.
This study enrolled 1984 Chinese women who were undergoing health check-ups. A univariate logistic regression analysis did not reveal a direct correlation between H. pylori infection and LSMM among this female population (OR=1.149, 95% CI 0.904-1.459, p=0.257). Yet, upon dividing the participants into age-based subgroups, an evident link was observed between H. pylori infection and LSMM in women aged 40 or above (OR=1.381, 95%CI 1.032-1.848, p= 0.030). After adjusting for variables including Age, BMI, TP, ALK, Cre, this relationship remained statistically relevant (OR=1.514, 95%CI 1.085-2.113, p= 0.015).
Women who are over 40 years old and currently infected with H. pylori have an increased risk of developing LSMM. Therefore, timely treatment for H. pylori eradication is recommended for this group of women to reduce the occurrence of LSMM.