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Abstract：
Individuals with mental health problems are at higher risk of musculoskeletal diseases. However, the association between low muscle mass (LMM) and anxiety symptoms remains uninvestigated. This cross-sectional study enrolled 174,262 adults (73,833 women, 100,429 men), aged 18 to 89, who completed the anxiety scale and body composition analyses. Using bio-electrical impedance analysis, skeletal muscle mass index (SMI) was calculated based on appendicular skeletal muscle mass (ASM) (kg)/height (m2). LMM was defined as SMI < 7.0 kg/m2 in men and <5.4 kg/m2 in women. Anxiety symptoms were screened using the Clinical Useful Anxiety Outcome Scale (CUXOS) with cut-off scores of 20, 30, and 40. Multivariable logistic regression analyses were performed. LMM prevalence was 20.17% in women, 3.86% in men (p < 0.001). The prevalence of anxiety symptoms in LMM group decreased from mild (CUXOS > 20: women, 32.74%, men, 21.17%) to moderate (CUXOS > 30: 13.34%, 7.32%), to severe anxiety symptoms (CUXOS > 40: 4.00%, 1.73%). In multivariable-adjusted models, LMM was associated with mild (aOR (95% confidence interval)), women, 1.13 (1.08-1.17); men, 1.17 (1.08-1.27)), moderate (1.17 (1.11-1.24); 1.35 (1.19-1.53) and severe anxiety symptoms (1.18 (1.07-1.3), 1.36 (1.06-1.74)), demonstrating an increased risk of ORs with escalating anxiety severity. LMM was independently associated with a higher prevalence of anxiety symptoms.
摘要：
有心理健康问题的人患肌肉骨骼疾病的风险更高。然而,低肌肉质量(LMM)与焦虑症状之间的关联仍未被研究.这项横断面研究招募了174,262名成年人（73,833名女性，100,429名男子），年龄在18至89岁之间，完成了焦虑量表和身体成分分析。使用生物电阻抗分析，骨骼肌质量指数(SMI)基于阑尾骨骼肌质量(ASM)(kg)/身高(m2)计算.LMM定义为男性SMI<7.0kg/m2,女性SMI<5.4kg/m2。使用临床有用焦虑结果量表（CUXOS）筛查焦虑症状，截止评分为20、30和40。进行多变量逻辑回归分析。女性LMM患病率为20.17％，男性为3.86%(p<0.001)。LMM组焦虑症状的患病率从轻度下降（CUXOS>20：女性，32.74%,男人,21.17%）至中等（CUXOS>30：13.34%，7.32%），严重的焦虑症状(CUXOS>40:4.00%，1.73%）。在多变量调整模型中，LMM与轻度相关(aOR(95%置信区间))，女人,1.13（1.08-1.17）；男性，1.17(1.08-1.27)),中度（1.17（1.11-1.24）；1.35（1.19-1.53）和严重的焦虑症状（1.18（1.07-1.3），1.36(1.06-1.74)),证明ORs的风险增加与焦虑严重程度的升级。LMM与较高的焦虑症状患病率独立相关。
