介绍:拉伸标记,或条纹(SD),是真皮在拉伸部位的线性萎缩引起的病变。由于皮肤拉伸,它们发生在70%以上的孕妇和青少年中。本研究旨在评估和比较分数CO2激光与长脉冲(LP)Nd:YAG激光治疗白纹的临床和组织学疗效。方法:对30例具有双侧对称妊娠纹的女性受试者进行右侧LPNd:YAG激光治疗,左侧分数CO2激光治疗。激光治疗过程包括3个疗程,间隔3周。在研究中采用患者满意度评分和整体美学改善量表(GAIS),以评估治疗后3个月的改善情况。在基线和最后一次治疗3个月后,从每侧的一个病变处提取4mm的穿刺活检,以评估胶原蛋白和表皮的厚度。结果:LPNd:YAG激光治疗的病变的临床改善更为显着。LPNd:YAG激光治疗的患者满意度评分和GAIS较高,具有统计学意义。LPNd:YAG激光治疗的病变中的胶原蛋白和表皮厚度增加得更多,而分数CO2激光管理的病变中的厚度相比,但这种差异没有统计学意义。结论:LPNd-YAG激光在治疗白纹方面的临床疗效超过了部分CO2激光,尽管两种激光之间的组织学差异不大,但没有严重的副作用。
Introduction: Stretch marks, or striae distensae (SD), are the lesions of the dermis caused by its linear atrophy at the sites of stretching. They occur in more than 70% of pregnant women and adolescents as a result of cutaneous stretching. This study aimed at evaluating and comparing the clinical and histological efficacy of the fractional CO2 laser versus the long pulsed (LP) Nd: YAG laser in the treatment of striae alba. Methods: Thirty female subjects having bilateral symmetrical stretch marks were managed by the LP Nd: YAG laser on the right side and the fractional CO2 laser on the left side. The laser treatment course consisted of 3 sessions with an interval of 3 weeks. The patient satisfaction score and the Global Aesthetic Improvement Scale (GAIS) were employed in the study in order to assess the improvement 3 months after therapy. Punch biopsies measuring 4 mm were extracted from one lesion on each side at baseline and after the last treatment session by 3 months to evaluate the thickness of both collagen and epidermis Results: Clinical improvement was more significant in the lesions treated by the LP Nd:YAG laser than those treated with the fractional CO2 laser. The patient satisfaction score and the GAIS were higher with a statistically significant value in the side treated by the LP Nd:YAG laser. Collagen and epidermal thickness increased more in the LP Nd: YAG laser-treated lesions in comparison to their thickness in the fractional CO2 laser-managed lesions, but this difference did not have a statistical significance. Conclusion: The clinical efficacy of the LP Nd-YAG laser exceeded that of the fractional CO2 laser in the treatment of striae alba without severe side effects in spite of the insignificant histological difference between the two lasers.