PDF(Pubmed)
Abstract：
Introduction: Stretch marks, or striae distensae (SD), are the lesions of the dermis caused by its linear atrophy at the sites of stretching. They occur in more than 70% of pregnant women and adolescents as a result of cutaneous stretching. This study aimed at evaluating and comparing the clinical and histological efficacy of the fractional CO2 laser versus the long pulsed (LP) Nd: YAG laser in the treatment of striae alba. Methods: Thirty female subjects having bilateral symmetrical stretch marks were managed by the LP Nd: YAG laser on the right side and the fractional CO2 laser on the left side. The laser treatment course consisted of 3 sessions with an interval of 3 weeks. The patient satisfaction score and the Global Aesthetic Improvement Scale (GAIS) were employed in the study in order to assess the improvement 3 months after therapy. Punch biopsies measuring 4 mm were extracted from one lesion on each side at baseline and after the last treatment session by 3 months to evaluate the thickness of both collagen and epidermis Results: Clinical improvement was more significant in the lesions treated by the LP Nd:YAG laser than those treated with the fractional CO2 laser. The patient satisfaction score and the GAIS were higher with a statistically significant value in the side treated by the LP Nd:YAG laser. Collagen and epidermal thickness increased more in the LP Nd: YAG laser-treated lesions in comparison to their thickness in the fractional CO2 laser-managed lesions, but this difference did not have a statistical significance. Conclusion: The clinical efficacy of the LP Nd-YAG laser exceeded that of the fractional CO2 laser in the treatment of striae alba without severe side effects in spite of the insignificant histological difference between the two lasers.
摘要：
介绍:拉伸标记,或条纹（SD），是真皮在拉伸部位的线性萎缩引起的病变。由于皮肤拉伸，它们发生在70％以上的孕妇和青少年中。本研究旨在评估和比较分数CO2激光与长脉冲（LP）Nd：YAG激光治疗白纹的临床和组织学疗效。方法：对30例具有双侧对称妊娠纹的女性受试者进行右侧LPNd：YAG激光治疗，左侧分数CO2激光治疗。激光治疗过程包括3个疗程，间隔3周。在研究中采用患者满意度评分和整体美学改善量表（GAIS），以评估治疗后3个月的改善情况。在基线和最后一次治疗3个月后，从每侧的一个病变处提取4mm的穿刺活检，以评估胶原蛋白和表皮的厚度。结果：LPNd：YAG激光治疗的病变的临床改善更为显着。LPNd：YAG激光治疗的患者满意度评分和GAIS较高，具有统计学意义。LPNd：YAG激光治疗的病变中的胶原蛋白和表皮厚度增加得更多，而分数CO2激光管理的病变中的厚度相比，但这种差异没有统计学意义。结论：LPNd-YAG激光在治疗白纹方面的临床疗效超过了部分CO2激光，尽管两种激光之间的组织学差异不大，但没有严重的副作用。
