汞(Hg)对人体健康有害,但其对脂质生物标志物的影响仍存在争议.这项研究试图描绘血液汞和与心血管疾病(CVD)相关的脂质生物标志物之间的明确联系。包括总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),和甘油三酯(TG),在美国的高血压成人中。
方法:这项横断面研究收集了来自全国健康和营养调查(NHANES)的4415名参与者的数据。Holm-Bonferroni降压程序用于控制多次比较中的I型错误率。我们采用多变量线性回归模型来评估血液Hg和脂质生物标志物之间的相关性。随后,进行了亚组分析,按性别和种族分类。此外,我们使用光滑曲线拟合和广义加性模型来确认非线性关系的存在。当检测到非线性时,我们应用递归算法来计算拐点。最后,我们建立了加权两分段线性回归模型来说明拐点两侧的关联。
结果:在我们的多元线性回归模型中,明确的关联出现了。具体来说,血汞与TC呈正相关(β=0.025;95%CI0.009~0.041;校正P=0.011),LDL-C(β=0.022;95%CI0.007至0.036;校正P=0.012),和HDL-C(β=0.007;95%CI0.001至0.013;校正P=0.058)。然而,与TG无显著相关性(β=-0.007;95%CI-0.018~0.004;校正P=0.526)。值得注意的是,在我们的分析中已经证明,当按性别分层时,存在明显的倒U形和U形曲线.
结论:血汞与TC呈正相关,LDL-C,和HDL-C在高血压成人在美国。尽管如此,与TG无显著关联。
Mercury (Hg) is detrimental to human health, but its impact on lipid biomarkers remains a subject of controversy. This study sought to delineate a clear link between blood Hg and lipid biomarkers correlated with cardiovascular disease (CVD), including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG), in hypertensive adults in the USA.
METHODS: This cross-sectional research gathered data from a total of 4415 participants sourced from the National Health and Nutrition Examination Survey (NHANES). The Holm-Bonferroni stepdown procedure was utilized to control the type I error rate in multiple comparisons. We employed multivariable linear regression models to assess the correlation between blood Hg and lipid biomarkers. Subsequently, subgroup analyses were conducted, categorized by both gender and race. Additionally, we used smooth curve fittings and generalized additive models to confirm the presence of non-linear relationships. When non-linearity was detected, we applied a recursive algorithm to calculate the inflection points. Finally, we established a weighted two-piecewise linear regression model to illustrate the associations on either side of the inflection point.
RESULTS: In our multivariable linear regression models, clear associations emerged. Specifically, positive correlations were observed between blood mercury and TC (β = 0.025; 95% CI 0.009 to 0.041; corrected P = 0.011), LDL-C (β = 0.022; 95% CI 0.007 to 0.036; corrected P = 0.012), and HDL-C (β = 0.007; 95% CI 0.001 to 0.013; corrected P = 0.058). However, there was no significant correlation with TG (β = - 0.007; 95% CI - 0.018 to 0.004; corrected P = 0.526). Notably, it has been demonstrated that distinct inverted U-shaped and U-shaped curves exist when stratified by gender in our analysis.
CONCLUSIONS: Blood Hg exhibited a positive correlation with TC, LDL-C, and HDL-C in hypertensive adults in the USA. Nonetheless, no significant association was observed with TG.