■路易体痴呆(DLB)患者及其护理人员的生活质量(QOL)和治疗需求是制定治疗策略时要考虑的重要因素。
■为了调查与DLB患者生活质量相关的因素,并检查与日常生活活动(ADL)相关的因素,如果ADL与QOL相关。
■我们先前进行了一项问卷调查研究,以调查DLB患者及其护理人员的治疗需求。这个预先指定的附加分析评估了QOL的简表8的身体成分评分(PCS)和心理成分评分(MCS),和运动障碍协会统一帕金森病评定量表(MDS-UPDRS)第二部分ADL总分。
■总共,包括231对患者-护理人员和38名医生。QOL的多变量分析表明,MDS-UPDRS第二部分总分(标准回归系数[β],-0.432)与PCS相关,和抑郁症的存在(β,-0.330)与MCS相关。姿势不稳定/步态障碍(PIGD)的严重程度(β,0.337)和刚度(β,0.266),存在幻觉(β,0.165),男性(β,0.157),并使用“短期停留”或“小规模”,多功能家庭护理“(β,0.156)与ADL恶化相关。
■在DLB患者中,生活质量受到ADL残疾和抑郁严重程度的负面影响,ADL受到PIGD严重程度和刚性的负面影响,幻觉,男性,并使用“短期停留”或“小规模”,多功能家庭护理。\"
UNASSIGNED: Quality of life (QOL) and treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers are important factors to consider when developing treatment strategies.
UNASSIGNED: To investigate factors associated with QOL in patients with DLB, and to examine factors associated with activities of daily living (ADL) if ADL was associated with QOL.
UNASSIGNED: We previously conducted a questionnaire survey study to investigate the treatment needs of patients with DLB and their caregivers. This pre-specified additional analysis evaluated the Physical Component Score (PCS) and Mental Component Score (MCS) of the Short Form-8 for QOL, and the Movement Disorder Society-Unified Parkinson\'s Disease Rating Scale (MDS-UPDRS) Part II total score for ADL.
UNASSIGNED: In total, 231 patient- caregiver pairs and 38 physicians were included. Multivariable analysis of QOL showed that the MDS-UPDRS Part II total score (standard regression coefficient [β], - 0.432) was associated with the PCS, and presence of depression (β, - 0.330) was associated with the MCS. The severity of postural instability/gait disorder (PIGD) (β, 0.337) and rigidity (β, 0.266), presence of hallucinations (β, 0.165), male sex (β, 0.157), and use of \"short stay\" or \"small-scale, multifunctional home care\" (β, 0.156) were associated with worsened ADL.
UNASSIGNED: In patients with DLB, QOL was negatively impacted by severity of ADL disability and depression, and ADL was negatively impacted by severity of PIGD and rigidity, hallucinations, male sex, and use of \"short stay\" or \"small-scale, multifunctional home care.\"