快速 iPSC 包涵体病变模型揭示了形成 ,后果 ,和 α - 突触核蛋白包裹体的分子亚型。
关键词: CRISPR screen Lewy body Parkinson’s disease Rab protein RhoA actin cytoskeleton aggregation dementia with Lewy bodies glia iPSC inclusion lipid neurodegeneration neuron p62 piggyBac proximity labeling synucleinopathy ubiquitin α-synuclein
Mesh : Induced Pluripotent Stem Cells / metabolism alpha-Synuclein / metabolism genetics Humans Inclusion Bodies / metabolism pathology Synucleinopathies / metabolism pathology genetics Neurons / metabolism pathology Brain / metabolism pathology
来 源:
DOI:10.1016/j.neuron.2024.06.002
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