背景:变应性鼻炎(AR)的治疗主要以常规药物为主,不良反应较多。白三烯受体拮抗剂,糖皮质激素和鼻抗组胺药都可以作为AR的一线药物,但这三种药物的临床效果尚不清楚。
目的:为了检查糖皮质激素的影响,抗组胺药,和白三烯受体拮抗剂对诊断为AR的个体,特别关注它们对血清炎症指标的影响。
方法:本研究回顾性分析我院2019年5月至2021年5月收治的80例AR患者的临床资料。将参与者分为对照组和观察组。对照组接受白三烯受体拮抗剂,观察组给予糖皮质激素和抗组胺药。对症状进行了观察和比较,体征分数,不良反应,以及对两组不同患者血清炎症指标的影响,治疗前和治疗后。
结果:治疗后,鼻痒评分,打喷嚏得分,流鼻涕得分,鼻塞评分,与体征评分差异显著(P<0.05),观察组治疗效果优于对照组(P<0.05)。白细胞介素(IL)-6,IL-10,肿瘤坏死因子-α,可溶性细胞间粘附分子-1、白三烯D4治疗后差异显著,且观察组优于对照组,有统计学意义(P<0.05)。干预之后,观察组不良反应发生率,包括鼻干等症状,喉咙不适,在口中苦涩的味道,和鼻粘膜的轻微侵蚀,被发现是7.5%。这一比率明显低于对照组,报告发生率为27.5%。两组比较差异有统计学意义(P<0.05)。
结论:糖皮质激素和抗组胺药有明显的治疗作用,降低血清炎症指标水平,缓解患者的症状和体征,促进患者康复,可为临床治疗AR提供参考。
BACKGROUND: There are many adverse reactions in the treatment of allergic rhinitis (AR) mainly with conventional drugs. Leukotriene receptor antagonists, glucocorticoids and nasal antihistamines can all be used as first-line drugs for AR, but the clinical effects of the three drugs are not clear.
OBJECTIVE: To examine the impact of glucocorticoids, antihistamines, and leukotriene receptor antagonists on individuals diagnosed with AR, specifically focusing on their influence on serum inflammatory indexes.
METHODS: The present retrospective study focused on the clinical data of 80 patients diagnosed and treated for AR at our hospital between May 2019 and May 2021. The participants were categorized into the control group and the observation group. The control group received leukotriene receptor antagonists, while the observation group was administered glucocorticoids and antihistamines. Conducted an observation and comparison of the symptoms, physical sign scores, adverse reactions, and effects on serum inflammatory indexes in two distinct groups of patients, both before and after treatment.
RESULTS: Subsequent to treatment, the nasal itching score, sneeze score, runny nose score, nasal congestion score, and physical signs score exhibited notable discrepancies (P < 0.05), with the observation group demonstrating superior outcomes compared to the control group (P < 0.05). The interleukin (IL)-6, IL-10, tumor necrosis factor-alpha, Soluble Intercellular Adhesion Molecule-1, Leukotriene D4 after treatment were significantly different and the observation group It is better than the control group, which is statistically significant (P < 0.05). Following the intervention, the incidence of adverse reactions in the observation group, including symptoms such as nasal dryness, discomfort in the throat, bitter taste in the mouth, and minor erosion of the nasal mucosa, was found to be 7.5%. This rate was significantly lower compared to the control group, which reported an incidence of 27.5%. The difference between the two groups was statistically significant (P < 0.05).
CONCLUSIONS: Glucocorticoids and antihistamines have obvious therapeutic effects, reduce serum inflammatory index levels, relieve symptoms and signs of patients, and promote patients\' recovery, which can provide a reference for clinical treatment of AR.