Abstract：
The association between the use of certain medications (including sulfonamides, hydralazine, and procainamide) and the occurrence of drug-induced lupus or hepatitis is well established. More recently, cases of immune-related adverse events ranging from inflammatory polyarthritis to necrotizing myositis in patients taking checkpoint inhibitors have been reported. However, data linking drugs to systemic vasculitis are scarce and at times debatable. Propylthiouracil, hydralazine, and minocycline have been associated with rare cases of ANCA-associated syndromes, including life-threatening pulmonary-renal syndromes and systemic polyarteritis nodosa-like diseases. Eosinophilic granulomatosis with polyangiitis (EGPA) has been reported in patients taking leukotriene inhibitors. Since the link between the use of leukotriene inhibitors and occurrence of EGPA remains highly controversial, we performed a literature review for cases of EGPA in patients taking montelukast without prior history of oral corticosteroid use. We found 24 cases, along with our own two cases described, making 26 cases in total. The mean age was 43 and a majority (18/26) were female. In majority of cases EGPA-like disease never relapsed after they were taken off leukotriene inhibitors suggesting a clear causal relationship between the use of these drugs and occurrence of eosinophil-rich systemic EGPA.
摘要：
使用某些药物（包括磺胺类药物，肼屈嗪,和普鲁卡因胺），并且药物诱导的狼疮或肝炎的发生已经确定。最近,有报道称,在服用检查点抑制剂的患者中,发生了从炎症性多关节炎到坏死性肌炎的免疫相关不良事件.然而,将药物与系统性血管炎联系起来的数据很少，有时还有争议。丙基硫氧嘧啶,肼屈嗪,米诺环素与罕见的ANCA相关综合征有关，包括危及生命的肺肾综合征和系统性多动脉炎结节性疾病。据报道，在服用白三烯抑制剂的患者中，嗜酸粒细胞肉芽肿性多血管炎（EGPA）。由于白三烯抑制剂的使用与EGPA的发生之间的联系仍然存在很大争议，我们对服用孟鲁司特而没有口服皮质类固醇史的患者的EGPA病例进行了文献综述.我们发现了24例,连同我们自己描述的两个案例，共26例。平均年龄为43岁，大多数（18/26）为女性。在大多数情况下，EGPA样疾病在停用白三烯抑制剂后从未复发，这表明这些药物的使用与富含嗜酸性粒细胞的全身性EGPA的发生之间存在明显的因果关系。
