■心脏手术通常需要大量的术后血管活性-正性肌力支持。鉴于关于白血病指数(LGI)[血清葡萄糖(mg/dl)×白细胞总数(细胞/mm3)/1000]的预后潜力的令人鼓舞的文献,我们的目的是评估重症监护病房(ICU)入院LGI是否可以预测心肺转流(CPB)心脏手术后血管加压素-肌力的需求.
对2015年1月至2020年12月在我们的三级护理中心接受心脏手术的患者的数据进行了回顾性分析。使用术后第一个72小时的VIS(血管活性-正性肌力评分)值估计血管加压药-正性肌力需求。随后,VISi(索引VIS)计算为maxVIS[0-24小时]+maxVIS[24-48小时]+2×maxVIS[48-72小时]/10),研究参与者分为h-VISi(VISi≥3)和l-VISi(VISi<3)。
■在2138名患者中,479例(22.40%)患者分类为h-VISi。关于单变量分析:LGI,年龄,欧洲心脏手术风险评估系统评分(EuroSCOREII),左心室射血分数,充血性心力衰竭(CHF),慢性肾功能衰竭,血管紧张素转换酶抑制剂,联合手术,CPB和主动脉交叉夹(ACC)持续时间,输血,术后即刻血糖是显著的h-VISi预测因子。在多变量分析之后,LGI的预测性能(OR:1.09;95%CI:1.03-1.14;P=0.002)先于CHF(OR:2.35;95%CI:1.44-3.82;P=0.001),CPB时间(OR:1.08;95%CI:1.02-1.14;P=0.019),ACC时间(OR:1.03;95%CI:1.02-1.04;P=0.008),和EuroSCOREII(OR:1.14;95%CI:1.06-1.21;P<0.001)仍然显著。随着1484.75成为h-VISi预测截止值,LGI≥1484.75的患者血管停搏的发生率也较高,低心输出量综合征,新发心房颤动,急性肾损伤,和死亡率。此外,LGI与机械通气时间和ICU住院时间呈显著正相关(R=0.495和0.564,P值<0.001)。
■大于1484.75的LGI升高独立预测CPB成人心脏手术后VISindex≥3。
UNASSIGNED: Cardiac surgery often necessitates considerable post-operative vasoactive-inotropic support. Given an encouraging literature on the prognostic potential of leucoglycemic index (LGI) [serum glucose (mg/dl) × total
leucocytes count (cells/mm3)/1000], we aimed to evaluate whether intensive care unit (ICU)-admission LGI can predict post-operative vasopressor-inotropic requirements following cardiac surgery on cardio-pulmonary bypass (CPB).
UNASSIGNED: The data of patients undergoing cardiac surgery at our tertiary care center between January 2015 and December 2020 was retrospectively reviewed. The vasopressor-inotropic requirement was estimated using the VIS (vasoactive-inotropic score) values over the first post-operative 72 hrs. Subsequently, VISi (indexed VIS) was computed as maxVIS[0-24hrs] + maxVIS[24-48hrs] +2 × maxVIS[48-72hrs]/10), and the study participants were divided into h-VISi (VISi ≥3) and l-VISi (VISi <3).
UNASSIGNED: Out of 2138 patients, 479 (22.40%) patients categorized as h-VISi. On univariate analysis: LGI, age, European System for Cardiac Operative Risk Evaluation score (EuroSCORE II), left-ventricle ejection fraction, prior congestive heart failure (CHF), chronic renal failure, angiotensin-converting enzyme inhibitors, combined surgeries, CPB and aortic cross-clamp (ACC) duration, blood transfusion, and immediate post-operative glucose were significant h-VISi predictors. Subsequent to multi-variate analysis, the predictive performance of LGI (OR: 1.09; 95% CI: 1.03-1.14; P = 0.002) prior CHF (OR: 2.35; 95% CI: 1.44-3.82; P = 0.001), CPB time (OR: 1.08; 95% CI: 1.02-1.14; P = 0.019), ACC time (OR: 1.03; 95% CI: 1.02-1.04; P = 0.008), and EuroSCORE II (OR: 1.14; 95% CI: 1.06-1.21; P < 0.001) remained significant. With 1484.75 emerging as the h-VISi predictive cut-off, patients with LGI ≥ 1484.75 also had a higher incidence of vasoplegia, low-cardiac output syndrome, new-onset atrial fibrillation, acute kidney injury, and mortality. LGI additionally exhibited a significant positive correlation with duration of mechanical ventilation and ICU stay (R = 0.495 and 0.564, P value < 0.001).
UNASSIGNED: An elevated LGI of greater than 1484.75 independently predicted a VISindex ≥3 following adult cardiac surgery on CPB.