背景:最近的ACOG实践公告没有提供关于少于24周具有严重特征的先兆子痫(带SF的PreE)的管理指南。历史上,由于围产期结局差和产妇发病率高,因此建议立即分娩.最近,新生儿复苏的进展导致围活产胎龄的存活率增加.
方法:我们的目的是报告在<24周时采用SF对PreE进行预期管理后的围产期和产妇结局。
方法:这是2017-2023年在IV级中心<24周时发生的带有SF的PreE回顾性病例系列。排除需要在诊断后24小时内分娩的个体。分析围产期和产妇结局。使用卡方检验将我们数据库中的分类变量与先前发布的数据进行了比较。
结果:有41例患者被诊断为SF<24周的PreE。在24小时内排除交货后,对30人(73%)进行了评估。诊断时的中位胎龄为22周(IQR22-23周)。16%有辅助生殖技术,27%有慢性高血压,13%有孕前糖尿病,30%有先兆子痫,73%的BMI>30kg/m2。22周和23周的中位潜伏期为7天(IQR4-23)和8天(IQR4-13天)。新生儿生存率为44%(95%CI3-85%),SF在22周时发作为29%(95%CI1-56%)。有2例急性肾损伤(7%)和2例心包/胸腔积液(7%)。在我们目前的研究中,围产期<24周的总生存率为30%,而在以前的报告中为7%(p=0.02)。
结论:对于在<24周时预期治疗患有SF的PreE的病例,我们的研究结果表明,与以前发表的数据相比,围产期生存率提高,孕产妇发病率降低.此信息可用于对SF<24周的PreE进行预期管理的咨询。
BACKGROUND: The recent American College of Obstetricians and Gynecologists Practice Bulletin offers no guidance on the management of preeclampsia with severe features at <24 weeks of gestation. Historically, immediate delivery was recommended because of poor perinatal outcomes and high maternal morbidity. Recently, advances in neonatal resuscitation have led to increased survival at periviable gestational ages.
OBJECTIVE: This study aimed to report perinatal and maternal outcomes after expectant management of preeclampsia with severe features at <24 weeks of gestation.
METHODS: This was a retrospective case series of preeclampsia with severe features at <24 weeks of gestation at a level 4 center between 2017 and 2023. Individuals requiring delivery within 24 hours of diagnosis were excluded. Perinatal and maternal outcomes were analyzed. Categorical variables from our database were compared with previously published data using chi-square tests.
RESULTS: A total of 41 individuals were diagnosed with preeclampsia with severe features at <24 weeks of gestation. After the exclusion of delivery within 24 hours, 30 individuals (73%) were evaluated. The median gestational age at diagnosis was 22 weeks (interquartile range, 22-23). Moreover, 16% of individuals had assisted reproductive technology, 27% of individuals had chronic hypertension, 13% of individuals had pregestational diabetes mellitus, 30% of individuals had previous preeclampsia, and 73% of individuals had a body mass index of >30 kg/m2. The median latency periods at 22 and 23 weeks of gestation were 7 days (interquartile range, 4-23) and 8 days (interquartile range, 4-13). In preeclampsia with severe features, neonatal survival rates were 44% (95% confidence interval, 3%-85%) at 22 weeks of gestation and 29% (95% confidence interval, 1%-56%) at 23 weeks of gestation. There were 2 cases of acute kidney injury (7%) and 2 cases of pericardial or pleural effusions (7%). Overall perinatal survival at <24 weeks of gestation was 30% in our current study vs 7% in previous reports (P=.02).
CONCLUSIONS: For cases of expectant management of preeclampsia with severe features at <24 weeks of gestation, our findings showed an increased perinatal survival rate with decreased maternal morbidity compared with previously published data. This information may be used when counseling on expectant management of preeclampsia with severe features at <24 weeks of gestation.