PDF(Pubmed)
Abstract：
Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed metastatic choriocarcinoma presumably of gestational origin, 8 years after the last pregnancy and 2 years after the last menstrual period. The patient was brought to the emergency room of a tertiary care centre in Muscat, Oman, in 2022 and was diagnosed with CC metastatic to the brain, spleen, lung and the kidney. The β-human chorionic gonadotrophin level was found to be raised (1,292,867 mIU/mL). The International Federation of Gynecologic Oncology risk score was calculated to be 14 (very high risk). The patient was initially treated with whole-brain radiotherapy and splenic artery embolisation because of a hemoperitoneum. Afterwards the patient received systemic treatment using the standard EMA/CO regimen till complete serological remission.
摘要：
绒毛膜癌（CC）是滋养组织的恶性肿瘤，有可能转移到远处的器官。在漫长的潜伏期后，发生了有限的妊娠CC病例。我们报告了一名52岁的绝经后妇女，她发展为转移性绒毛膜癌，可能是妊娠起源，最后一次怀孕后8年和最后一次月经期后2年。病人被送往马斯喀特一家三级护理中心的急诊室,阿曼,在2022年被诊断为CC转移到大脑，脾,脾肺和肾.发现β-人绒毛膜促性腺激素水平升高（1,292,867mIU/mL）。国际妇科肿瘤联合会风险评分计算为14（非常高风险）。由于腹膜积血，该患者最初接受了全脑放疗和脾动脉栓塞治疗。之后,患者接受使用标准EMA/CO方案的全身治疗直至完全血清学缓解。
