系统性红斑狼疮(SLE)是一种侵袭人体大部分器官的全球性慢性自身免疫性疾病,肾损伤是最突出的特征。外泌体是携带多种蛋白质的细胞外囊泡，脂质和遗传物质，参与本地和系统间信息的交流，在多种自身免疫性疾病中发挥重要的免疫调节作用。同时,外泌体作为疾病生物标志物和药物递送载体的应用也显示出巨大的应用前景。本文就目前外泌体在发病机制中的应用进展作一综述。SLE的诊断和治疗。
Systemic lupus erythematosus (SLE) is a global chronic autoimmune disease that invades most organs of the body, with kidney injury being the most prominent feature. Exosomes are extracellular vesicles that carry a variety of proteins, lipids and genetic material, participate in the exchange of local and intersystem information, and play an important immunoregulatory role in a variety of autoimmune diseases. At the same time, the use of exosomes as disease biomarkers and drug delivery carriers also shows great application prospects. This article reviews current progress in the application of exosomes in the pathogenesis, diagnosis and treatment of SLE.
PDF(Pubmed)