目标:肾结石病(KSD),发达国家和发展中国家的重大医疗保健问题,与遗传风险因素有关。同样,有人假设体力活动与KSD风险之间存在关联,但研究结果不一致.本研究旨在探讨体力活动强度与KSD发生率之间的关系,该关系是遗传风险的原因。
方法:前瞻性队列研究。
方法:来自英国生物库研究的80,473名参与者。
方法:身体活动水平,包括总体力活动(TPA),中等至剧烈强度的体力活动(MVPA),和光强度体力活动(LPA),使用加速度计进行测量,并使用机器学习模型进行量化。还构建了KSD的多基因风险评分(PRS)。
结果:使用第10版国际疾病分类确定患有KSD的个体,和KSD手术的程序代码。
方法:使用精细和灰色生存模型来估计事件KSD与TPA的关联,MVPA,LPA,和PRS(作为分类变量)。使用受限制的三次样条来检查完全调整模型内的潜在非线性关联。
结果:在平均6.19年的随访中,421名参与者开发了KSD。TPA最高四分位数的参与者,MVPA,与最低四分位数相比,LPA的KSD调整率较低:HR(95%置信区间)为0.50(0.44,0.56),0.57(0.51,0.64),和0.66(0.59,0.74),分别。TPA,MVPA,在具有低和高KSD遗传易感性的参与者中,LPA和LPA与较低的KSD风险相关。
结论:选择偏倚作为提供加速度测量数据的参与者可能更坚持医疗保健。
结论:体力活动与KSD的风险呈负相关,无论遗传风险如何。未来的大型研究有必要确认和解释这些关联的潜在机制。
OBJECTIVE: Kidney stone disease (KSD), a significant health care problem within both developed and developing countries, has been associated with genetic risk factors. An association between physical activity and KSD risk also has been hypothesized, but studies have yielded inconsistent findings. This study investigated the association between the intensity of physical activity and the incidence of KSD accounting for genetic risk.
METHODS: Prospective cohort study.
METHODS: A total of 80,473 participants from the UK Biobank Study.
METHODS: Physical activity levels, including total physical activity (TPA), moderate-to-vigorous intensity physical activity (MVPA), and light-intensity physical activity (LPA), were measured using accelerometers and quantified using a machine learning model. A polygenic risk score (PRS) for KSD was also constructed.
RESULTS: Individuals with KSD were identified using the International Classification of Diseases, Tenth Revision (ICD-10), and procedure codes for KSD surgery.
METHODS: A Fine and Gray survival model was used to estimate the associations of incident KSD with TPA, MVPA, LPA, and PRS (as categorical variables). Restricted cubic splines were used to examine potential nonlinear associations within the fully adjusted models.
RESULTS: During an average follow-up of 6.19 years, 421 participants developed KSD. Participants in the highest quartiles of TPA, MVPA, and LPA had lower adjusted rates of KSD compared with those in the lowest quartiles: HR, 0.50 (95% CI, 0.44-0.56), 0.57 (95% CI, 0.51-0.64), and 0.66 (95% CI, 0.59-0.74), respectively. TPA, MVPA, and LPA were associated with a lower risk of KSD in participants with low and high genetic predisposition for KSD.
CONCLUSIONS: Selection bias as participants who provided accelerometry data may have been more adherent to health care.
CONCLUSIONS: Physical activity was negatively associated with the risk of KSD, regardless of the genetic risk. Future large studies are warranted to confirm and explain the mechanisms underlying these associations.
UNASSIGNED: The association between the intensity of physical activity (PA) and the incidence of kidney stone disease (KSD) after accounting for genetic risk is unclear. We conducted a comprehensive prospective cohort study utilizing participants from the UK Biobank to assess the intensity of PA using accelerometers. Our study findings indicated that greater total PA, moderate-to-vigorous-intensity PA, and light-intensity PA were each associated with a lower risk of KSD irrespective of an individual\'s genetic risk. Our study informs the understanding of risk factors for KSD.