PDF(Pubmed)
Abstract：
BACKGROUND: Inflammatory bowel diseases (IBDs), including Crohn\'s disease and ulcerative colitis, have been increasingly associated with kidney stone disease, posing significant health challenges globally.
OBJECTIVE: This research sought to determine the causal relationship between kidney stone disease risk and inflammatory bowel disorders.
METHODS: This retrospective cohort study included patients with IBDs, such as ulcerative colitis or Crohn\'s disease, who were diagnosed at least 18 years of age. Information was gathered with an emphasis on patients having comprehensive medical histories and confirmed cases of kidney stone disease from January to December 2022. Medical records were retrospectively evaluated by trained staff to extract treatment information and clinical, radiological, and demographic data. To evaluate relationships, statistical analysis was carried out in SPSS software version 23 using Chi-square tests and descriptive statistics.
RESULTS: The study included 320 patients diagnosed with IBDs, among which 198 (61.87%) had Crohn\'s disease, and 122 (38.13%) were diagnosed with ulcerative colitis. The cohort consisted of 140 females (43.75%) and 180 men (56.25%), with a mean age of 45.5 years. Regarding smoking, 113 people (35.31%) reported being smokers, whereas 207 people (64.69%) did not smoke. Additionally, 18 (5.62%) of the population had an underweight BMI, 136 (42.50%) had a normal BMI, 119 (37.19%) had an overweight BMI, and 47 (14.69%) had an obese BMI. Of the patients, 86 (26.88%) had a prior history of kidney stone disease, while 194 (60.62%) did not. Aminosalicylates were the most often used therapy modality for IBD in 189 (58.97%) of cases, followed by corticosteroids in 117 (36.56%) and immunomodulators in 93 (28.94%). Radiological examinations showed that renal calculi were present in 60 (18.75%) of patients, and kidney stones occurred in 40 (12.50%) of patients throughout the research period. The smoking status (p=0.006) and prior history of kidney stones (p<0.001) were the corresponding p-values for the significant results.
CONCLUSIONS: The study highlights an increased risk of kidney stone disease in IBD patients, particularly among smokers and those with a recurrent history of kidney stones. Of the 320 patients, 198 (61.87%) had Crohn\'s disease and 122 (38.13%) had ulcerative colitis, with a significant relationship found between kidney stones and both smoking (113 patients, 35.31%, p=0.006) and a prior history of kidney stones (86 patients, 26.88%, p<0.001). The findings emphasize the need for targeted preventive measures and close monitoring of these high-risk groups.
OBJECTIVE: This research sought to determine the causal relationship between kidney stone disease risk and inflammatory bowel disorders.
METHODS: This retrospective cohort study included patients with IBDs, such as ulcerative colitis or Crohn\'s disease, who were diagnosed at least 18 years of age. Information was gathered with an emphasis on patients having comprehensive medical histories and confirmed cases of kidney stone disease from January to December 2022. Medical records were retrospectively evaluated by trained staff to extract treatment information and clinical, radiological, and demographic data. To evaluate relationships, statistical analysis was carried out in SPSS software version 23 using Chi-square tests and descriptive statistics.
RESULTS: The study included 320 patients diagnosed with IBDs, among which 198 (61.87%) had Crohn\'s disease, and 122 (38.13%) were diagnosed with ulcerative colitis. The cohort consisted of 140 females (43.75%) and 180 men (56.25%), with a mean age of 45.5 years. Regarding smoking, 113 people (35.31%) reported being smokers, whereas 207 people (64.69%) did not smoke. Additionally, 18 (5.62%) of the population had an underweight BMI, 136 (42.50%) had a normal BMI, 119 (37.19%) had an overweight BMI, and 47 (14.69%) had an obese BMI. Of the patients, 86 (26.88%) had a prior history of kidney stone disease, while 194 (60.62%) did not. Aminosalicylates were the most often used therapy modality for IBD in 189 (58.97%) of cases, followed by corticosteroids in 117 (36.56%) and immunomodulators in 93 (28.94%). Radiological examinations showed that renal calculi were present in 60 (18.75%) of patients, and kidney stones occurred in 40 (12.50%) of patients throughout the research period. The smoking status (p=0.006) and prior history of kidney stones (p<0.001) were the corresponding p-values for the significant results.
CONCLUSIONS: The study highlights an increased risk of kidney stone disease in IBD patients, particularly among smokers and those with a recurrent history of kidney stones. Of the 320 patients, 198 (61.87%) had Crohn\'s disease and 122 (38.13%) had ulcerative colitis, with a significant relationship found between kidney stones and both smoking (113 patients, 35.31%, p=0.006) and a prior history of kidney stones (86 patients, 26.88%, p<0.001). The findings emphasize the need for targeted preventive measures and close monitoring of these high-risk groups.
摘要：
背景：炎症性肠病（IBDs），包括克罗恩病和溃疡性结肠炎，越来越多地与肾结石疾病相关，对全球健康构成重大挑战。
目的：本研究试图确定肾结石疾病风险与炎症性肠病之间的因果关系。
方法：这项回顾性队列研究包括IBDs患者，如溃疡性结肠炎或克罗恩病，被诊断为至少18岁。收集的信息重点是2022年1月至12月具有全面病史和确诊肾结石病例的患者。医疗记录由训练有素的工作人员进行回顾性评估，以提取治疗信息和临床，放射学,和人口统计数据。要评估关系，采用SPSS软件23版进行统计学分析,采用卡方检验和描述性统计.
结果：该研究包括320名诊断为IBDs的患者，其中198人（61.87%）患有克罗恩病，122例(38.13%)被诊断为溃疡性结肠炎。该队列由140名女性（43.75％）和180名男性（56.25％）组成，平均年龄45.5岁.关于吸烟，113人(35.31%)报告是吸烟者，207人(64.69%)不吸烟。此外,18（5.62%）的人口体重指数偏低，136（42.50%）的BMI正常，119（37.19％）的BMI超重，和47（14.69％）有肥胖的BMI。在患者中，86（26.88%）有肾结石病史，而194（60.62%）没有。在189例（58.97%）病例中，氨基水杨酸盐是IBD最常用的治疗方式，其次是皮质类固醇117（36.56％）和免疫调节剂93（28.94％）。放射学检查显示60例(18.75%)患者出现肾结石,在整个研究期间，40例(12.50%)患者发生肾结石。吸烟状态（p=0.006）和肾结石病史（p<0.001）是显着结果的相应p值。
结论：这项研究强调了IBD患者肾结石的风险增加，特别是吸烟者和有肾结石复发史的人。在320名患者中，198（61.87%）患有克罗恩病，122（38.13%）患有溃疡性结肠炎，发现肾结石与吸烟之间存在显著关系(113例患者，35.31%,p=0.006）和肾结石病史（86例，26.88%,p<0.001)。调查结果强调，需要采取有针对性的预防措施，并密切监测这些高危人群。
目的：本研究试图确定肾结石疾病风险与炎症性肠病之间的因果关系。
方法：这项回顾性队列研究包括IBDs患者，如溃疡性结肠炎或克罗恩病，被诊断为至少18岁。收集的信息重点是2022年1月至12月具有全面病史和确诊肾结石病例的患者。医疗记录由训练有素的工作人员进行回顾性评估，以提取治疗信息和临床，放射学,和人口统计数据。要评估关系，采用SPSS软件23版进行统计学分析,采用卡方检验和描述性统计.
结果：该研究包括320名诊断为IBDs的患者，其中198人（61.87%）患有克罗恩病，122例(38.13%)被诊断为溃疡性结肠炎。该队列由140名女性（43.75％）和180名男性（56.25％）组成，平均年龄45.5岁.关于吸烟，113人(35.31%)报告是吸烟者，207人(64.69%)不吸烟。此外,18（5.62%）的人口体重指数偏低，136（42.50%）的BMI正常，119（37.19％）的BMI超重，和47（14.69％）有肥胖的BMI。在患者中，86（26.88%）有肾结石病史，而194（60.62%）没有。在189例（58.97%）病例中，氨基水杨酸盐是IBD最常用的治疗方式，其次是皮质类固醇117（36.56％）和免疫调节剂93（28.94％）。放射学检查显示60例(18.75%)患者出现肾结石,在整个研究期间，40例(12.50%)患者发生肾结石。吸烟状态（p=0.006）和肾结石病史（p<0.001）是显着结果的相应p值。
结论：这项研究强调了IBD患者肾结石的风险增加，特别是吸烟者和有肾结石复发史的人。在320名患者中，198（61.87%）患有克罗恩病，122（38.13%）患有溃疡性结肠炎，发现肾结石与吸烟之间存在显著关系(113例患者，35.31%,p=0.006）和肾结石病史（86例，26.88%,p<0.001)。调查结果强调，需要采取有针对性的预防措施，并密切监测这些高危人群。
