背景:尽管了解了COP9信号体亚基5(CSN5)在肿瘤发生中的作用,其对消化系统肿瘤患者生存和预后的预测价值尚无定论。因此,本研究旨在评估CSN5水平对消化系统肿瘤患者生存和临床病理参数的影响。
方法:首先,在四个数据库中进行了全面搜索。我们利用风险比(HR)和95%置信区间(CI)评估CSN5对患者总生存期(OS)和无复发生存期(RFS)的预后价值。然后,我们根据比值比(OR)和相应的95%CI估计了CSN5与临床病理参数之间的联系.
结果:这项荟萃分析包括22项研究和2193例诊断为消化系统肿瘤的患者。CSN5的高表达与OS较差相关(HR=2.28,95%CI:1.71-3.03;p<0.00001)。此外,高CSN5水平与更差的侵袭深度相关(OR=0.49,95%CI:0.25-0.96,p=0.04),淋巴结转移阳性(OR=0.28,95%CI:0.16-0.47,p=0.00001),远处转移阳性(OR=0.32,95%CI:0.13~0.76,p=0.01),分化程度较差(OR=0.34,95%CI:0.19~0.60,p=0.0003)。然而,我们没有检测到CSN5表达与年龄之间的相关性,性别,肿瘤分期,肿瘤大小或血管侵犯。此外,未检测到显著的发表偏倚.
结论:这项荟萃分析表明,CSN5水平的过表达可能预示消化系统癌症患者的OS较差。此外,CSN5水平可能与消化系统肿瘤的预后有关。
BACKGROUND: Despite the understanding of the COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on its value to predict the survival and prognosis of digestive system tumor patients. Hence this study aimed to evaluate the impact of CSN5 levels on the survival and clinicopathological parameters of digestive system neoplasm patients.
METHODS: First, a comprehensive search was conducted in four databases. We utilized the Hazard Ratio (HR) with a 95% confidence interval (CI) to evaluate the prognostic value of CSN5 for the overall survival (OS) and recurrence-free survival (RFS) of patients. Then, we estimated the connection between CSN5 and the clinicopathological parameters based on the Odds Ratio (OR) with the corresponding 95% CI.
RESULTS: This meta-analysis included 22 studies and 2193 patients diagnosed with digestive system tumors. High expression of CSN5 was correlated to poorer OS (HR = 2.28, 95% CI: 1.71-3.03; p < 0.00001). Additionally, high CSN5 levels were correlated with worse invasion depth (OR = 0.49, 95% CI: 0.25-0.96, p = 0.04), positive lymphatic metastasis (OR = 0.28, 95% CI: 0.16-0.47, p = 0.00001), positive distant metastasis (OR = 0.32, 95% CI: 0.13-0.76, p = 0.01) and poorer differentiation degree (OR = 0.34, 95% CI: 0.19-0.60, p = 0.0003). However, we did not detect a correlation between CSN5 expression and age, gender, tumor stage, tumor size or vascular invasion. Furthermore, no significant publication bias was detected.
CONCLUSIONS: This meta-analysis demonstrated that the overexpression of CSN5 level might foresee poorer OS in digestive system cancer patients. Additionally, CSN5 levels might be related to the prognosis of digestive system tumors.