■左心室高梁/心肌致密化不全(LVHT)是一种发病机制不明的心脏异常,经常与神经肌肉疾病有关。冠状动脉疾病(CAD)与LVHT的相关性尚不清楚。本研究旨在评估CAD作为LVHT预后标志物的作用。
■LVHT患者的数据从超声心动图实验室收集。回顾性筛查了医院信息系统的冠状动脉造影。CAD与临床的关联,超声心动图,和神经基线参数进行评估。终点是全因死亡和心脏移植。
■共有154名患者(平均[SD]年龄,57[13.7]岁;31%的女性)在1995年至2020年期间接受冠状动脉造影检查的患者被纳入研究。冠状动脉造影在154名患者中的53名患者中发现了CAD。冠心病患者年龄较大(平均[SD]年龄为,64.2[12.9]年vs52.7[12.4]年;P<.001);更频繁地出现心绞痛(P=.05),糖尿病(P=0.002),和高血压(P=0.03);并且与没有CAD的患者相比,更频繁地出现3个或更多的心电图异常(P=.04)。在6.48(2.44-11.20)年的中位(IQR)随访期内,39%的患者达到终点(死亡,n=56;心脏移植,n=4)。死亡率为每年4.5%,有和没有CAD的患者的死亡率或心脏移植率没有差异(P=0.26)。3支血管疾病患者的预后比1支或2支血管疾病患者差(P=0.046)。
■在LVHT患者中,CAD似乎与死亡率或心脏移植的增加无关。
UNASSIGNED: Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality of unknown pathogenesis, frequently associated with neuromuscular disorders. The relevance of coronary artery disease (CAD) in LVHT is largely unknown. This study aimed to assess the role of CAD as a prognostic marker in LVHT.
UNASSIGNED: Data from patients with LVHT were collected from an echocardiographic laboratory. The hospital information system was retrospectively screened for coronary angiography. The association of CAD with clinical, echocardiographic, and neurologic baseline parameters was assessed. End points were all-cause death and heart transplantation.
UNASSIGNED: A total of 154 patients (mean [SD] age, 57 [13.7] years; 31% female) who had undergone coronary angiography between 1995 and 2020 were included in the study. Coronary angiography disclosed CAD in 53 of 154 patients. Patients with CAD were older (mean [SD] age of, 64.2 [12.9] years vs 52.7 [12.4] years; P < .001); more frequently had angina pectoris (P = .05), diabetes (P = .002), and hypertension (P = .03); and more frequently had 3 or more electrocardiographic abnormalities (P = .04) than patients without CAD. During a median (IQR) follow-up period of 6.48 (2.44-11.20) years, 39% of patients reached an end point (death, n = 56; heart transplantation, n = 4). Mortality was 4.5% per year, and the rate of death or heart transplantation did not differ between patients with and without CAD (P = .26). Patients with 3-vessel disease had a worse prognosis than patients with 1- or 2-vessel disease (P = .046).
UNASSIGNED: In patients with LVHT, CAD does not appear to be associated with an increased rate of death or heart transplantation.