■评估选择性激光小梁成形术(SLT)在原发性闭角型青光眼(PAC)和原发性闭角型青光眼(PACG)后进行激光周边虹膜切开术(LPI)的长期疗效。
■在这项前瞻性横断面研究中,34例PAC/PACG诊断患者45只眼,不受控制的眼内压(IOP),并在LPI后的房角镜检查上至少180°可见的色素小梁网(TM)被招募。在详细的基线眼科评估之后,所有符合条件的眼睛都接受了SLT,患者在第1天,第1周接受检查,1-,3-,6个月,1-,2-,3-,4-,此后5年。测量的主要结果是眼压,降低IOP的药物数量,和并发症。
■该队列的平均年龄为57.80±6.44岁,男女比例为8:26,17只眼为PACG,28个是PAC。基线眼压为23.81±1.78mmHg,并且在所有随访中均显着下降(p<0.0001)。2-时,总体成功的累积概率为91%和84%,5年,分别。在5年时,SLT在80%的PAC和23%的PACG眼中提供了药物自由度。六只眼睛在1周时出现IOP峰值,两名患者在1年后再次接受SLT。没有其他并发症,如疼痛/不适,炎症,外周前粘连和黄斑囊样水肿的增加,被注意到。
■SLT在激光虹膜切开术后眼压失控的PAC/中度PACG眼中是一种安全且具有成本效益的手术。SLT作为辅助治疗的长期有效性良好,但需要大型随机研究以进行更多验证。
UNASSIGNED: To evaluate the long-term efficacy of selective laser trabeculoplasty (SLT) in eyes with primary angle-closure (PAC) and primary angle-closure glaucoma (PACG) following a laser peripheral iridotomy (LPI).
UNASSIGNED: In this prospective cross-sectional study, 45 eyes of 34 patients with PAC/PACG diagnosis, uncontrolled intraocular pressure (IOP), and visible pigmented trabecular-meshwork (TM) at least 180° on gonioscopy following a LPI were recruited. Following a detailed baseline ophthalmic evaluation, all eligible eyes underwent SLT, and the patients were examined on day1, at 1 week, 1-, 3-, and 6-months, and 1-, 2-, 3-, 4-, and 5-year subsequently. The main outcomes measured were IOP, number of IOP-lowering agents, and complications.
UNASSIGNED: The mean age of the cohort was 57.80 ± 6.44 years, the male-female ratio was 8:26, and 17 eyes were PACG, and 28 were PAC. The baseline IOP was 23.81 ± 1.78 mm Hg, and was significantly declined at all follow-ups (p < .0001). The cumulative probability of overall success was 91% and 84% at 2-, and 5-year, respectively. At 5-year SLT provided drug-freedom in 80% of PAC and 23% of PACG eyes. Six eyes had IOP spike at 1-week and two patients underwent repeat SLT after 1-year. No other complications, such as pain/discomfort, inflammation, an increase in peripheral anterior synechiae and cystoid-macular-edema, were noted.
UNASSIGNED: SLT appears a safe and cost-effective procedure in PAC/mild- moderate PACG eyes with uncontrolled IOP after laser iridotomy. The long-term effectiveness of SLT as adjuvant treatment was good, but need large sized randomized studies for more validation.