瓦里安精神,一个新的治疗平台,能够自动生成初始计划和在线治疗计划,适应性规划,使用智能优化引擎(IOE)。这项研究的主要目的是评估VarianEthosIOE用于自动计划的功效,并在Ethos治疗计划系统(TPS)中比较不同的治疗方式。本研究共选择36例回顾性前列腺和近端精囊病例。处方剂量为50.4Gy,分为28个部位到近端精囊,同时对前列腺进行70Gy的综合增强。基于RT的意图,在EthosTPS中自动生成了三个治疗计划,并将其导出到EclipseTPS,以与Eclipse治疗计划进行比较。当针对相同的计划目标体积(PTV)覆盖范围进行归一化时,精神计划Dmax%为108.1±1.2%,108.4±1.6%,和109.6±2.0%,对于9场IMRT,12场IMRT,和2个完整弧的VMAT计划,分别。这与Eclipse计划Dmax%值比较好,为108.8±1.4%。还使用放射治疗肿瘤学组报告0415作为指导对Ethos计划的OAR指数进行了评估,发现它们与Eclipse计划具有可比性。虽然所有Ethos计划都是可比的,我们发现,总的来说,Ethos12场IMRT计划满足了大部分治疗剂量目标.此外,与IMRT计划相比,EthosIOE始终生成剂量学上更热的VMAT计划。平均而言,EthosTPS花了13分钟生成2-fullarcVMAT计划,与12场IMRT计划的5分钟相比。VarianEthosTPS可以在有效的时间范围内生成多个治疗计划,并且与手动生成的治疗计划相比,计划的质量可以被认为是临床上可接受的。
Varian Ethos, a new treatment platform, is capable of automatically generating treatment plans for initial planning and for online, adaptive planning, using an intelligent optimization engine (IOE). The primary purpose of this study is to assess the efficacy of Varian Ethos IOE for auto-planning and intercompare different treatment modalities within the Ethos treatment planning system (TPS). A total of 36 retrospective prostate and proximal seminal vesicles cases were selected for this study. The prescription dose was 50.4 Gy in 28 fractions to the proximal seminal vesicles, with a simultaneous integrated boost of 70 Gy to the prostate gland. Based on RT intent, three treatment plans were auto-generated in the Ethos TPS and were exported to the Eclipse TPS for intercomparison with the Eclipse treatment plan. When normalized for the same planning target volume (PTV) coverage, Ethos plans Dmax% were 108.1 ± 1.2%, 108.4 ± 1.6%, and 109.6 ± 2.0%, for the 9-field IMRT, 12-field IMRT, and 2-full arc VMAT plans, respectively. This compared well with Eclipse plan Dmax% values, which was 108.8 ± 1.4%. OAR indices were also evaluated for Ethos plans using Radiation Therapy Oncology Group report 0415 as a guide and were found to be comparable to each other and the Eclipse plans. While all Ethos plans were comparable, we found that, in general, the Ethos 12-field IMRT plans met most of the dosimetric goals for treatment. Also, Ethos IOE consistently generated dosimetrically hotter VMAT plans versus IMRT plans. On average, Ethos TPS took 13 min to generate 2-full arc VMAT plans, compared to 5 min for 12-field IMRT plans. Varian Ethos TPS can generate multiple treatment plans in an efficient time frame and the quality of the plans could be deemed clinically acceptable when compared to manually generated treatment plans.