PDF(Pubmed)
Abstract：
UNASSIGNED: The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning system (aTPS) for both intensity-modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) plan creation. The purpose of this study is to evaluate the quality of aTPS plans in the pelvic region.
UNASSIGNED: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS. Three IMRT (7-, 9- and 12-field) and two VMAT (2 and 3 arc) automatically generated plans (APs) were created per patient. The duration of the automated plan generation was registered. The best IMRT-AP and VMAT-AP for each patient were selected based on target coverage and dose to organs at risk (OARs). The AP quality was analyzed and compared to corresponding clinically accepted and manually generated VMAT plans (MPs) using several clinically relevant dose metrics. Calculation-based pre-treatment plan quality assurance (QA) was performed for all plans.
UNASSIGNED: The median total duration to generate the five APs with the aTPS was 55 min, 39 min and 35 min for anal, prostate and rectal plans, respectively. The target coverage and the OAR sparing were equivalent for IMRT-APs and VMAT-MPs, while VMAT-Aps.demonstrated lower target dose homogeneity and higher dose to some OARs. Both conformity and homogeneity index were equivalent (rectal) or better (anal and prostate) for IMRT-APs compared to VMAT-MPs. All plans passed the patient-specific QA tolerance limit.
UNASSIGNED: The aTPS generates plans comparable to MPs within a short time-frame which is highly relevant for oART treatments.
UNASSIGNED: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS. Three IMRT (7-, 9- and 12-field) and two VMAT (2 and 3 arc) automatically generated plans (APs) were created per patient. The duration of the automated plan generation was registered. The best IMRT-AP and VMAT-AP for each patient were selected based on target coverage and dose to organs at risk (OARs). The AP quality was analyzed and compared to corresponding clinically accepted and manually generated VMAT plans (MPs) using several clinically relevant dose metrics. Calculation-based pre-treatment plan quality assurance (QA) was performed for all plans.
UNASSIGNED: The median total duration to generate the five APs with the aTPS was 55 min, 39 min and 35 min for anal, prostate and rectal plans, respectively. The target coverage and the OAR sparing were equivalent for IMRT-APs and VMAT-MPs, while VMAT-Aps.demonstrated lower target dose homogeneity and higher dose to some OARs. Both conformity and homogeneity index were equivalent (rectal) or better (anal and prostate) for IMRT-APs compared to VMAT-MPs. All plans passed the patient-specific QA tolerance limit.
UNASSIGNED: The aTPS generates plans comparable to MPs within a short time-frame which is highly relevant for oART treatments.
摘要：
UNASSIGNED：Ethos系统通过实施用于强度调制放射治疗（IMRT）和体积调制电弧放射治疗（VMAT）计划创建的自动化治疗计划系统（aTPS），实现了在线自适应放射治疗（oART）。本研究的目的是评估骨盆地区aTPS计划的质量。
未经授权：60例肛门患者（n=20），用aTPS回顾性重新计划直肠癌(n=20)或前列腺癌(n=20).三个IMRT（7-，9场和12场）和每个患者创建两个VMAT（2和3弧）自动生成的计划（AP）。已注册自动计划生成的持续时间。根据目标覆盖率和对危险器官（OAR）的剂量选择每位患者的最佳IMRT-AP和VMAT-AP。使用几种临床相关剂量度量来分析AP质量并与相应的临床接受和手动生成的VMAT计划(MP)进行比较。对所有计划进行基于计算的预处理计划质量保证（QA）。
UNASSIGNED：生成具有aTPS的五个AP的平均总持续时间为55分钟，肛门39分钟和35分钟，前列腺和直肠计划，分别。IMRT-AP和VMAT-MP的目标覆盖率和OAR节省是等效的，而VMAT-Aps.对某些OAR表现出较低的目标剂量均匀性和较高的剂量。与VMAT-MP相比，IMRT-AP的一致性和均匀性指数均相等（直肠）或更好（肛门和前列腺）。所有计划均通过了患者特定的QA耐受限值。
UASSIGNED：aTPS在短时间内生成与MP相当的计划，这与oART治疗高度相关。
未经授权：60例肛门患者（n=20），用aTPS回顾性重新计划直肠癌(n=20)或前列腺癌(n=20).三个IMRT（7-，9场和12场）和每个患者创建两个VMAT（2和3弧）自动生成的计划（AP）。已注册自动计划生成的持续时间。根据目标覆盖率和对危险器官（OAR）的剂量选择每位患者的最佳IMRT-AP和VMAT-AP。使用几种临床相关剂量度量来分析AP质量并与相应的临床接受和手动生成的VMAT计划(MP)进行比较。对所有计划进行基于计算的预处理计划质量保证（QA）。
UNASSIGNED：生成具有aTPS的五个AP的平均总持续时间为55分钟，肛门39分钟和35分钟，前列腺和直肠计划，分别。IMRT-AP和VMAT-MP的目标覆盖率和OAR节省是等效的，而VMAT-Aps.对某些OAR表现出较低的目标剂量均匀性和较高的剂量。与VMAT-MP相比，IMRT-AP的一致性和均匀性指数均相等（直肠）或更好（肛门和前列腺）。所有计划均通过了患者特定的QA耐受限值。
UASSIGNED：aTPS在短时间内生成与MP相当的计划，这与oART治疗高度相关。
