■代谢综合征(MetS)是一组预测心血管疾病的代谢危险因素。先前的研究表明,MetS损害了接受体外受精(IVF)的多囊卵巢综合征(PCOS)女性的临床结局。
■评估MetS对无PCOS女性IVF/卵胞浆内单精子注射(ICSI)结局的影响。
■这项回顾性研究收集了8539名没有PCOS的合格妇女,这些妇女参加了第一个IVF/ICSI周期的妇女,儿童与生殖健康,山东大学,从2017年到2020年,包括MetS组1147名受试者和对照组7392名受试者。主要结果是活产。次要结局包括其他妊娠结局以及孕产妇和新生儿并发症的风险。
■MetS组的女性活产率较低(50.6%对54.9%,调整后的赔率比[aOR]0.87,95%CI0.75-1.00,P=0.045)和更高的晚期流产风险(5.8%vs3.3%,OR1.52,95%CI1.02-2.27,P=.041),妊娠期糖尿病(13.7%vs7.0%,OR1.84,95%CI1.30-2.60,P=.001),妊娠期高血压疾病(7.8%vs3.5%,OR1.79,95%CI1.14-2.83,P=.012),和早产(9.0%vs4.4%,OR2.03,95%CI1.33-3.08,P=.001)。MetS组中的单胎新生儿胎龄较大的风险较高(33.3%vs20.5%,OR1.66,95%CI(1.31-2.13),P<.001),但胎龄小的风险较低(2.7%vs6.2%,OR0.48,95%CI0.25-0.90,P=0.023)。
■MetS与没有PCOS的女性IVF/ICSI不良结局相关。
UNASSIGNED: Metabolic syndrome (MetS) is a cluster of metabolic risk factors that predict cardiovascular disease. Previous studies suggested that MetS impaired clinical outcomes in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF).
UNASSIGNED: To evaluate the effects of MetS on IVF/intracytoplasmic sperm injection (ICSI) outcomes in women without PCOS.
UNASSIGNED: This retrospective study collected 8539 eligible women without PCOS who came for their first cycle of IVF/ICSI to the Institute of Women, Children and Reproductive Health, Shandong University, from 2017 to 2020, including 1147 subjects in the MetS group and 7392 in the control group. The primary outcome was live birth. Secondary outcomes included other pregnancy outcomes and the risk of maternal and neonatal complications.
UNASSIGNED: Women in the MetS group had a lower live birth rate (50.6% vs 54.9%, adjusted odds ratio [aOR] 0.87, 95% CI 0.75-1.00, P = .045) and higher risks of late miscarriage (5.8% vs 3.3%, aOR 1.52, 95% CI 1.02-2.27, P = .041), gestational diabetes mellitus (13.7% vs 7.0%, aOR 1.84, 95% CI 1.30-2.60, P = .001), hypertensive disorder of pregnancy (7.8% vs 3.5%, aOR 1.79, 95% CI 1.14-2.83, P = .012), and preterm birth (9.0% vs 4.4%, aOR 2.03, 95% CI 1.33-3.08, P = .001). Singleton newborns in the MetS group were at higher risk of large for gestational age (33.3% vs 20.5%, aOR 1.66, 95% CI (1.31-2.13), P < .001) but at lower risk of small for gestational age (2.7% vs 6.2%, aOR 0.48, 95% CI 0.25-0.90, P = .023).
UNASSIGNED: MetS was associated with adverse IVF/ICSI outcomes in women without PCOS.