■有关亚洲间质性肺病(ILD)流行病学的公开数据很少。了解流行病学对于健康管理计划中的主管部门很重要。这项研究旨在估计患病率,发病率,2005年至2020年香港ILD的生存率,并评估了其随时间的变化趋势。
■在这项回顾性队列研究中,我们使用全港电子健康记录数据库确定了2005年至2020年之间的ILD患者.患病率,发病率,并以2020年联合国人口为参考,估计了年龄和性别标准化的发病率.使用连接点回归分析了患病率和发病率的趋势,并估计了平均年变化百分比(AAPC)。中位生存率,使用Cox比例风险回归评估死亡的危险因素。
■我们确定了5924例患者,其中5884例用于分析。从2005年到2020年,ILD的患病率从每100,000人口中的24.7增加到33.6,AAPC为1.94(95%置信区间,CI:1.69-2.34)。从2005年到2020年,标准化发病率从每100,000人5.36降至2.57(AAPC-3.56,95%CI,-4.95至-1.78)。ILD的中位生存期为2.50(95%CI,2.32-2.69)年。男性,年龄较大,更高的Charlson合并症指数,和IIP亚型与死亡率增加相关,具有统计学意义。
■这项研究首次对香港的ILD进行了流行病学评估。有必要在多个亚洲城市和国家对ILD进行进一步研究。
■无。
UNASSIGNED: Published data on the epidemiology of interstitial lung disease (ILD) in Asia is scarce. Understanding the epidemiology is important for authorities in the health management planning. This study aimed to estimate the prevalence, incidence, and survival of ILD in Hong Kong from 2005 to 2020 and evaluate the change of trend over time.
UNASSIGNED: In this retrospective cohort study, we identified ILD patients between 2005 and 2020 using a territory-wide electronic health record database. Prevalence, incidence rates, and age- and sex-standardised incidence rates with United Nations population in 2020 as a reference were estimated. Trends in prevalence and incidence were analysed using joinpoint regression and the average annual percent change (AAPC) was estimated. Median survival, and risk factors of mortality were evaluated using Cox proportional hazard regression.
UNASSIGNED: We identified 5924 patients and included 5884 of them for analysis. The prevalence of ILD increased from 24.7 to 33.6 per 100,000 population from 2005 to 2020 with an AAPC of 1.94 (95% confidence interval, CI: 1.69-2.34). The standardized incidence rate decreased from 5.36 to 2.57 per 100,000 person from 2005 to 2020 (AAPC -3.56, 95% CI, -4.95 to -1.78). The median survival of ILD was 2.50 (95% CI, 2.32-2.69) years. Male, older age, higher Charlson comorbidity index, and IIP subtype were associated with increased mortality with statistical significance.
UNASSIGNED: This study provided the first epidemiological evaluation of ILD in Hong Kong. Further studies on ILD in multiple Asian cities and countries are warranted.
UNASSIGNED: None.