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Abstract：
Background: There are only a few reports on the nutritional status and mortality of patients with idiopathic pulmonary fibrosis (IPF). As such, this study aims to investigate the relationship between controlling nutritional status (CONUT) and the mortality of elderly patients with IPF. Methods: A total of 170 IPF patients aged ≥65 years old who visited the rehabilitation department of our hospital between July 2014 and July 2021 (mean age: 75.7 ± 6.3 years, sex (male/female): 138/32, %FVC: 78.3 ± 18.3%) were retrospectively analyzed. The Kaplan-Meier method and log-rank test were applied. Furthermore, using a Cox proportional hazards model with multivariate analysis, we analyzed the relationship between all-cause mortality and baseline characteristics including CONUT. Results: Based on the CONUT score, the normal group included 101 cases, the mild group included 58 cases, the moderate group included 11 cases, and the severe group had 0 cases. There were 49 cases of all-cause mortality events, suggesting that the mortality of the moderate group was significantly poorer than that of the normal and mild groups (p < 0.05). Furthermore, multivariate analysis identified GAP stage (HR: 5.972, 95%CI: 2.901~12.291, p < 0.0001), mMRC scale (HR: 0.615, 95%CI: 0.389~0.971, p = 0.009), and CONUT (HR: 2.012, 95%CI: 1.192~3.395, p = 0.037) as factors significantly influencing mortality. Conclusions: Severe malnutrition was not observed in elderly patients with IPF. Moderate malnutrition was associated with a significantly higher risk of all-cause mortality, suggesting that CONUT is an important indicator for predicting mortality.
摘要：
背景：关于特发性肺纤维化（IPF）患者的营养状况和死亡率的报道很少。因此，本研究旨在探讨控制营养状况(CONUT)与老年IPF患者死亡率的关系。方法:选取2014年7月至2021年7月在我院康复科就诊的年龄≥65岁的IPF患者170例(平均年龄:75.7±6.3岁,性别(男/女):138/32,%FVC:78.3±18.3%。采用Kaplan-Meier法和对数秩检验。此外，使用Cox比例风险模型和多变量分析，我们分析了全因死亡率与包括CONUT在内的基线特征之间的关系.结果：根据CONUT得分，正常组101例,轻度组58例,中度组包括11例，重症组0例。有49例全因死亡事件，表明中度组的死亡率明显低于正常组和轻度组（p<0.05）。此外，多变量分析确定了GAP阶段(HR:5.972,95CI:2.901~12.291,p<0.0001),mMRC量表(HR:0.615,95CI:0.389~0.971,p=0.009),和CONUT（HR：2.012，95CI：1.192〜3.395，p=0.037）是显着影响死亡率的因素。结论：老年IPF患者未出现严重营养不良。中度营养不良与全因死亡率的风险显著增高有关。表明CONUT是预测死亡率的重要指标。
