背景:神经影像学研究已确定特发性宫颈肌张力障碍(iCD)患者的大脑结构和功能异常,但往往会产生不同的结果。我们的目标是通过在结构和功能神经影像学研究中进行单独和多模态的荟萃分析,发现iCD中特定和常见的神经结构/功能异常。
方法:进行了系统的文献检索以确定相关出版物。全脑基于体素的形态计量学(VBM)研究和功能成像研究的单独荟萃分析,使用基于各向异性效应大小的符号差分映射进行了跨VBM和iCD功能研究的多模态荟萃分析。
结果:我们纳入了27项研究,包括9个结构数据集,包括152名iCD患者和188名健康对照,和17个功能数据集,描述了352名iCD患者和296名健康对照。多模态分析显示双侧中央前和中央后回的解剖和功能变化重叠,双侧中央旁小叶,右侧辅助电机区域,双侧正中扣带/副带回,右尾状核和丘脑,右小脑和舌回。我们还发现双侧背外侧额上回仅有灰质改变,左颞中回,右顶叶下回,和左小脑;右梭形回的功能活动改变,双侧前叶。
结论:当前的荟萃分析揭示了iCD中显著的联合和分离的脑结构和功能异常,并强调了皮质-丘脑-基底神经节回路和小脑的受累。
BACKGROUND: Neuroimaging studies have identified both brain structural and functional abnormalities in patients with idiopathic cervical dystonia (iCD), but often yield diverse results. We aim to find the specific and common neurostructural/functional abnormalities in iCD by conducting separate and multimodal meta-analyses across structural and functional neuroimaging studies.
METHODS: A systematic literature search was conducted to identify relevant publications. Separate meta-analysis for whole-brain voxel-based morphometry (VBM) studies and for functional imaging studies, and a multimodal meta-analysis across VBM and functional studies in iCD were conducted using anisotropic effect size-based signed differential mapping.
RESULTS: We included twenty-seven studies, including nine structural datasets comprising 152 iCD patients and 188 healthy controls, and seventeen functional datasets describing 352 iCD patients and 296 healthy controls. The multimodal analysis showed overlap between anatomic and functional changes in bilateral precentral and postcentral gyri, bilateral paracentral lobules, right supplementary motor area, bilateral median cingulate/paracingulate gyri, right caudate nucleus and thalamus, right cerebellum and lingual gyrus. We also found gray matter alterations alone in bilateral dorsolateral superior frontal gyri, left middle temporal gyrus, right inferior parietal gyrus, and left cerebellum; and altered functional activity alone in right fusiform gyrus, bilateral precuneus.
CONCLUSIONS: The current meta-analyses revealed significant conjoint and dissociated brain structural and functional abnormalities in iCD, and emphasized the involvement of cortico-thalamo-basal ganglia circuit and cerebellum.