Ghrelin广泛存在于中枢神经系统和外周器官中,并具有生物活性,如维持能量稳态,调节脂质代谢,细胞增殖,免疫反应,胃肠生理活动,认知,记忆,昼夜节律和奖励效应。在许多良性肝脏疾病中,它可能对脂肪变性起到保肝作用,慢性炎症,氧化应激,线粒体功能障碍,内质网应激与细胞凋亡,改善肝细胞自噬和免疫反应,改善疾病进展。然而,Ghrelin在肝包虫病中的作用目前尚不清楚.本文系统地总结了Ghrelin调节肝脏生长代谢的分子机制,免疫炎症,纤维发生,增殖和凋亡,以及它在肝纤维化疾病中的保护作用,并进一步提出Ghrelin在肝棘球蚴感染中的作用。在感染过程中,它可能通过改善免疫炎症微环境和纤维化状态来促进寄生虫在宿主上的寄生和存活,从而加速疾病进展。然而,目前缺乏针对这一观点的靶向体外和体内实验证据。
Ghrelin widely exists in the central nervous system and peripheral organs, and has biological activities such as maintaining energy homeostasis, regulating lipid metabolism, cell proliferation, immune response, gastrointestinal physiological activities, cognition, memory, circadian rhythm and reward effects. In many benign liver diseases, it may play a hepatoprotective role against steatosis, chronic inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress and apoptosis, and improve liver cell autophagy and immune response to improve disease progression. However, the role of Ghrelin in liver Echinococcosis is currently unclear. This review systematically summarizes the molecular mechanisms by which Ghrelin regulates liver growth metabolism, immune-inflammation, fibrogenesis, proliferation and apoptosis, as well as its protective effects in liver fibrosis diseases, and further proposes the role of Ghrelin in liver Echinococcosis infection. During the infectious process, it may promote the parasitism and survival of parasites on the host by improving the immune-inflammatory microenvironment and fibrosis state, thereby accelerating disease progression. However, there is currently a lack of targeted in vitro and in vivo experimental evidence for this viewpoint.