PDF(Pubmed)
Abstract：
Acromegaly is a rare endocrine disorder caused by hypersecretion of growth hormone (GH) from a pituitary adenoma. Elevated GH levels stimulate excess production of insulin-like growth factor 1 (IGF-1) which leads to the insidious onset of clinical manifestations. The most common primary central nervous system (CNS) tumors, meningiomas originate from the arachnoid layer of the meninges and are typically benign and slow-growing. Meningiomas are over twice as common in women as in men, with age-adjusted incidence (per 100,000 individuals) of 10.66 and 4.75, respectively. Several reports describe co-occurrence of meningiomas and acromegaly. We aimed to determine whether patients with acromegaly are at elevated risk for meningioma. Investigation of the literature showed that co-occurrence of a pituitary adenoma and a meningioma is a rare phenomenon, and the majority of cases involve GH-secreting adenomas. To the best of our knowledge, a systematic review examining the association between meningiomas and elevated GH levels (due to GH-secreting adenomas in acromegaly or exposure to exogenous GH) has never been conducted. The nature of the observed coexistence between acromegaly and meningioma -whether it reflects causation or mere co-association -is unclear, as is the pathophysiologic etiology.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42022376998.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42022376998.
摘要：
肢端肥大症是一种罕见的内分泌疾病，由垂体腺瘤的生长激素（GH）分泌过多引起。GH水平升高会刺激胰岛素样生长因子1（IGF-1）的过量产生，从而导致临床表现的隐匿发作。最常见的原发性中枢神经系统（CNS）肿瘤，脑膜瘤起源于脑膜的蛛网膜层，通常是良性和缓慢生长的。脑膜瘤在女性中的发病率是男性的两倍多，年龄调整后的发病率（每100,000人）分别为10.66和4.75。一些报告描述了脑膜瘤和肢端肥大症的同时发生。我们的目的是确定肢端肥大症患者患脑膜瘤的风险是否升高。对文献的调查表明，垂体腺瘤和脑膜瘤的同时发生是一种罕见的现象，大多数病例涉及GH分泌腺瘤。据我们所知,从未对脑膜瘤与GH水平升高(由于肢端肥大症中的GH分泌腺瘤或暴露于外源性GH)之间的关系进行过系统评价.所观察到的肢端肥大症和脑膜瘤之间共存的性质-无论是反映因果关系还是仅仅是共同关联-尚不清楚。病理生理学病因也是如此。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42022376998。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42022376998。
