■镁(Mg)是维持重要生理功能的必需营养素。镁缺乏与肥胖等疾病有关,2型糖尿病(T2DM),和代谢综合征(MetS);然而,结论不一致,在45岁以上的中国人群中,这种关联尤其缺乏证据。本研究旨在评估血浆镁与MetS及其组分风险之间的关联。剂量-反应关系,以及45岁以上中国人群的阈值效应关系。
■通过考虑监测点,从中国营养与健康监测(CNHS)(2015-2017)中随机选择了2,101名个体。我们使用2009年国际糖尿病联合会(IDF)的联合声明来定义MetS参与者。通过电感耦合等离子体质谱法(ICP-MS)测试等离子体镁。采用Logistic回归和有限三次样条(RCS)模型分析血浆Mg与MetS及其组分之间的关联和剂量-反应关系。
■与血浆Mg的最低五分之一(Q1)相比,MetS的比值比(OR)和95%置信区间(95%CI),空腹血糖受损(IFG),高血压,最高五分位数(Q5)的甘油三酯(TG)升高为0.419(0.301,0.583),0.303(0.221,0.415),0.446(0.322,0.618),和0.526(0.384,0.720),分别,所有p<0.05。然而,在高密度脂蛋白胆固醇(HDL-C)和中心性肥胖的成分中,未观察到血浆镁含量升高的趋势降低(p=0.717,p=0.865).这些关联不会因进一步调整潜在的混杂变量而改变,包括年龄,性别,教育,国籍,area,residence,体重指数(BMI),和心率。RCS分析表明,当血浆镁低于0.85mmol/L时,曲线被拉平了,然后,随着血浆镁的增加,曲线呈下降趋势。
■因此,血浆Mg与MetS及其成分呈负相关(包括IFG,高血压,和升高的TG)在45岁以上的人。此外,血浆Mg大于或等于0.85mmol/L,高于常用阈值0.75mmol/L,可能对MetS及其组件(包括升高的FPG,血压升高,和升高的TG)。更多前瞻性研究,如随机对照试验,有必要确认Mg对MetS及其组分的有效影响。年龄超过45岁的MetS人群中的血浆Mg水平需要注意。
UNASSIGNED: Magnesium (Mg) is an essential nutrient for the maintenance of vital physiological functions. Magnesium deficiency is associated with diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS); however, conclusions have been inconsistent, and there is a particular lack of evidence regarding this association in Chinese population older than 45 years. This study aimed to assess the association between plasma magnesium and the risk of MetS and its components, the dose-response relationship, and the threshold effect relationship in a Chinese population involving older than 45 years.
UNASSIGNED: A total of 2,101 individuals were randomly selected from the China Nutrition and Health Surveillance (CNHS) (2015-2017) by considering monitoring points. We used the joint statement of the International Diabetes Federation (IDF) in 2009 to define participants with MetS. The plasma magnesium was tested by inductively coupled plasma mass spectrometry (ICP-MS). The logistic regression and restricted cubic spline (RCS) models were used to analyze the association and dose-response relationship between plasma Mg and MetS and its components.
UNASSIGNED: Compared with the lowest quintile (Q1) for plasma Mg, the odds ratios (ORs) and 95% confidence intervals (95% CI) for MetS, impaired fasting glucose (
IFG), hypertension, and triglyceride (TG) elevation at the highest quintile (Q5) were 0.419 (0.301, 0.583), 0.303 (0.221, 0.415), 0.446 (0.322, 0.618), and 0.526 (0.384, 0.720), respectively, with all p < 0.05. However, in the components of decreased high-density lipoprotein cholesterol (HDL-C) and central obesity, no trend toward lowering with higher plasma magnesium was observed (p = 0.717, p = 0.865). These associations were not altered by further adjustment for potential confounding variables, including age, gender, education, nationality, area, residence, body mass index (BMI), and heart rate. The RCS analysis showed that, when plasma magnesium was lower than 0.85 mmol/L, the curve was leveled off, and then, the curve showed a decreasing trend with the increase in plasma magnesium.
UNASSIGNED: Therefore, plasma Mg was negatively associated with MetS and its components (including
IFG, hypertension, and elevated TG) in people older than 45 years. In addition, plasma Mg greater than or equal to 0.85 mmol/L, which is higher than the commonly used threshold of 0.75 mmol/L, may be protective against MetS and its components (including elevated FPG, elevated blood pressure, and elevated TG). More prospective studies, such as randomized controlled trials, are necessary to confirm the effective impact of Mg on MetS and its components. Plasma Mg levels in the MetS population older than 45 years require attention.