背景:髌腱病(PT)是跳台运动员的常见问题。管理可能是具有挑战性的,治疗结果并不总是成功的。结合肌腱负荷练习,水解胶原蛋白/维生素C补充剂似乎对肌腱病的恢复具有有希望的作用。这项研究的目的是评估口服补充水解胶原蛋白和维生素C与渐进性肌腱负荷运动(PTLE)结合使用VISA-P评分是否优于PTLE和安慰剂(这会导致疼痛,函数,运动参与)在PT运动员24周后。
方法:JUMPFOOD研究是双盲的,双臂随机对照试验,其中将研究口服补充水解胶原蛋白/维生素C联合PTLE与PTLE联合安慰剂对PT运动员疼痛和功能恢复的有效性。76名16-40岁的运动员,出现PT症状至少12周,每周至少做一次运动的人也包括在内。所有参与者都将接受教育,根据荷兰膝关节前疼痛指南,关于负荷管理和PTLE计划的建议。此外,干预组每天接受10g水解胶原蛋白和40mg维生素C补充剂,为期24周,而对照组接受10g麦芽糊精安慰剂补充剂。测量将在基线和12周和24周随访时进行。主要结果是VISA-P评分,评估疼痛,函数,体育参与。对于次要结果指标,关于功能测试期间疼痛的数据,灵活性测量,抽血,肌腱的影像学特征,并收集健康问卷。在后续期间,参与者将注册体育参与,训练量和肌腱负荷,运动过程中的疼痛,联合用药,以及数字每周日记中的副作用。
结论:JUMPFOOD研究是第一个研究水解胶原蛋白/维生素C补充剂与PTLE计划联合应用于髌腱病运动员的有效性的大型RCT。如果补充胶原蛋白/维生素C似乎有效,这种治疗可以在日常运动医学实践中实施,以改善PT患者的治疗效果。
背景:ClinicalTrials.govNCT05407194。2022年6月7日注册
BACKGROUND: Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is not always successful. In combination with tendon loading exercises, hydrolyzed collagen/vitamin C supplementation appears to have a promising effect on the recovery of tendinopathy. The aim of this study is to evaluate whether the use of oral supplementation of hydrolyzed collagen and vitamin C in combination with progressive tendon loading exercises (PTLE) is superior to PTLE and placebo on VISA-P score (which rates pain, function, sports participation) after 24 weeks for athletes with PT.
METHODS: The JUMPFOOD study is a double-blinded, two-armed randomized controlled trial, in which the effectiveness of oral supplementation of hydrolyzed collagen/vitamin C combined with PTLE compared to PTLE with placebo on pain and recovery of function in athletes with PT will be investigated. Seventy-six athletes aged 16-40 years, with symptoms of PT for at least 12 weeks, who play sports at least once a week will be included. All participants will receive education, advice with regard to load management and a PTLE program according to the Dutch guidelines for anterior knee pain. In addition, the intervention group will receive daily 10 g hydrolyzed collagen and 40 mg vitamin C supplementation for 24 weeks whereas the control group receives 10 g maltodextrin placebo supplementation. Measurements will take place at baseline and at 12 and 24 weeks\' follow-up. Primary outcome is the VISA-P score, which evaluates pain, function, and sports participation. For secondary outcome measures, data with regard to pain during functional tests, flexibility measurements, blood withdrawals, imaging characteristics of the tendon, and health questionnaires will be collected. During the follow-up period, participants will register sports participation, amount of training and tendon load, pain during sports, co-medication, and side-effects in a digital weekly diary.
CONCLUSIONS: The JUMPFOOD study is the first large RCT to study the effectiveness of hydrolyzed collagen/vitamin C supplementation in combination with the PTLE program in athletes with patellar tendinopathy. If supplementation of collagen/vitamin C appears to be effective, this treatment can be implemented in daily sports medicine practice to improve the treatment outcome of patients with PT.
BACKGROUND: ClinicalTrials.gov NCT05407194. Registered on 7 June 2022.