背景:西班牙裔占美国人口的19%,并且癌症发病率正在上升,主要是由于感染相关癌症的增加(胃癌,肝,宫颈癌)和晚期癌症继发于延迟筛查(结直肠癌,子宫颈,breast).胃癌的发病率增加(与感染有关,肥胖,酒精,和烟草使用)在西班牙裔,尤其是在年轻的时候,强调需要考虑种族作为一个风险因素。
方法:本研究利用2016-2019年全国住院患者样本数据库检查所有胃癌患者。个人按种族分层,年龄,和合并症,包括与胃癌相关的可改变的危险因素。
结果:年龄在18-44岁的患者为5,785(7.44%),年龄在45-64岁的患者为28,370(36.49%),65岁以上的患者为43,590(56.07%)。值得注意的是,34.3%的最年轻的群体是西班牙裔,与老年组的19.7%和12.9%相比,分别。与年龄较大的西班牙裔相比,年轻的西班牙裔患者的幽门螺杆菌感染率更高(8.6%)(中年组的3.6%和年龄最大的2.1%,p<0.01)。肥胖的患病率很高,烟草使用,和胃溃疡。其他危险因素如饮酒和胃息肉的患病率较低。
结论:这项研究表明,西班牙裔患者的胃癌发病年龄较小,再加上年轻时幽门螺杆菌感染的发病率增加。这一发现强调了在无症状的年轻西班牙裔人群中进行幽门螺杆菌筛查的潜在益处,目的是降低该人群的胃癌发病率和死亡率。
BACKGROUND: Hispanics make up 19% of the U.S. population and are experiencing rising rates of cancer, primarily due to an increase in infection-related cancers (gastric, hepatic, cervical) and advanced cancers secondary to delayed screening (colorectal, cervical, breast). There is an increased incidence of gastric cancer (associated with infection, obesity, alcohol, and tobacco use) in Hispanics, especially at a young age, highlighting the need to consider ethnicity as a risk factor.
METHODS: This study utilized the 2016-2019 National Inpatient Sample database to examine all patients admitted with gastric cancer. Individuals were stratified by race, age, and comorbidities, including modifiable risk factors that are associated with gastric cancer.
RESULTS: There were 5,785 (7.44%) patients aged 18-44, 28,370 (36.49%) aged 45-64, and 43,590 (56.07%) over 65 years of age. Notably, 34.3% of the youngest group were Hispanic, contrasted with 19.7% and 12.9% in the older groups, respectively. Younger Hispanic patients showed a higher prevalence of H. pylori infection (8.6%) compared with older Hispanics (3.6% in the middle age group and 2.1% in the oldest, p<0.01). There was a high prevalence of obesity, tobacco use, and gastric ulcers in this cohort. Other risk factors such as alcohol use and gastric polyps were present at a lesser prevalence.
CONCLUSIONS: This study reveals that Hispanic patients tend to have a younger age of onset of gastric cancer, coupled with an increased incidence of H. pylori infection at a younger age. This finding underscores the potential benefit of H. pylori screening among asymptomatic young Hispanics with the aim of reducing gastric cancer morbidity and mortality in this population.