背景:最近,门失弛缓症的发病率一直在增加,但其原因仍然未知。这项研究旨在检查最初的症状和症状的过程,并找到对疾病的原因和过程的新见解。
方法:总之,纳入了通过高分辨率测压(HRM)诊断为门失弛缓症的136例患者。进行问卷调查和图表回顾以调查初始症状,从发病到诊断的时间,和合并症,以及人力资源管理结果之间的关系,诊断时间到了,和症状严重程度。
结果:总计,136名患者中有67名回答了问卷。发病和诊断的中位年龄分别为42岁和58岁,分别。从发病到确诊的中位时间为78.6个月,25例(37.3%)需要10年以上才能被诊断。52例(77.6%)和11例(16.4%)患者的症状发作是逐渐和突然的,分别。在11例急性发作患者中,三人(27.3%)同时发生无汗症。从发病到诊断的时间与食管扩张之间没有相关性,静息LES压力,或平均积分松弛压(IRP)。症状程度与静息LES压力或IRP之间也没有发现相关性。
结论:食管失弛缓症可以有急性或隐伏性发作。这一发现可能有助于阐明贲门失弛缓症的病因。
BACKGROUND: Recently, the incidence of achalasia has been increasing, but its cause remains unknown. This study aimed to examine the initial symptoms and the course of symptoms and to find new insights into the cause and course of the disease.
METHODS: Altogether, 136 patients diagnosed with achalasia by high-resolution manometry (HRM) were enrolled. Questionnaires and chart reviews were conducted to investigate the initial symptoms, time from onset to diagnosis, and comorbidities, as well as the relationship between HRM results, time to diagnosis, and symptom severity.
RESULTS: In total, 67 of 136 patients responded to the questionnaire. The median ages of onset and diagnosis were 42 and 58 years, respectively. The median time from onset to diagnosis was 78.6 months, with 25 cases (37.3%) taking > 10 years to be diagnosed. The symptom onset was gradual and sudden in 52 (77.6%) and 11 (16.4%) patients, respectively. Of the 11 patients with acute onset, three (27.3%) developed anhidrosis at the same time. There was no correlation between the time from onset to diagnosis and esophageal dilatation, resting LES pressure, or mean integrated relaxation pressure (IRP). No correlation was also found between the degree of symptoms and resting LES pressure or IRP.
CONCLUSIONS: Esophageal achalasia can have acute or insidious onsets. This finding may help to elucidate the cause of achalasia.