PDF(Pubmed)
Abstract：
UNASSIGNED: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. The aims of our study included (1) to assess esophageal motility patterns of EoE by topographic analysis of high-resolution manometry (HRM) and (2) to establish a relationship between symptoms of EoE and motility abnormalities seen on HRM.
UNASSIGNED: A retrospective study in which all adult patients over 18 years of age with EoE diagnosed by endoscopy and histology and who underwent HRM were included in the study during the study period. Motility patterns in patients with EoE under HRM were analyzed. Data were presented as frequencies and percentages with inference by Pearson\'s chi-square test or Fisher\'s exact test.
UNASSIGNED: Seven hundred patients diagnosed with EoE were noted, and of these, 38 patients had undergone esophageal HRM. Fifty-eight percent of these patients were noted to have an esophageal motility abnormality on HRM. Thirty-seven percent of the patients showed absent peristalsis with pan-esophageal pressurization but normal integrate relaxation pressure; 21% of the patients showed peristaltic dysfunction; and 42% of the patients had a normal HRM. Seventy-one percent of the patients with pan-esophageal pressurization presented with food impaction requiring endoscopy for disimpaction and esophageal dilation (P = .015).
UNASSIGNED: The most common abnormality noted was aperistalsis with pan-esophageal pressurization. This abnormality correlated with the clinical presentation of bolus impaction requiring an endoscopic intervention (P = .015).
UNASSIGNED: A retrospective study in which all adult patients over 18 years of age with EoE diagnosed by endoscopy and histology and who underwent HRM were included in the study during the study period. Motility patterns in patients with EoE under HRM were analyzed. Data were presented as frequencies and percentages with inference by Pearson\'s chi-square test or Fisher\'s exact test.
UNASSIGNED: Seven hundred patients diagnosed with EoE were noted, and of these, 38 patients had undergone esophageal HRM. Fifty-eight percent of these patients were noted to have an esophageal motility abnormality on HRM. Thirty-seven percent of the patients showed absent peristalsis with pan-esophageal pressurization but normal integrate relaxation pressure; 21% of the patients showed peristaltic dysfunction; and 42% of the patients had a normal HRM. Seventy-one percent of the patients with pan-esophageal pressurization presented with food impaction requiring endoscopy for disimpaction and esophageal dilation (P = .015).
UNASSIGNED: The most common abnormality noted was aperistalsis with pan-esophageal pressurization. This abnormality correlated with the clinical presentation of bolus impaction requiring an endoscopic intervention (P = .015).
摘要：
■嗜酸性粒细胞性食管炎（EoE）是一种免疫介导的食道疾病，其特征是与食道功能障碍和嗜酸性粒细胞占优势的炎症相关的症状。我们研究的目的包括（1）通过高分辨率测压（HRM）的地形图分析评估EoE的食管运动模式，以及（2）建立EoE症状与HRM上看到的运动异常之间的关系。
■一项回顾性研究，在研究期间，所有18岁以上经内镜和组织学诊断为EoE并接受HRM的成年患者均纳入研究。分析了HRM下EoE患者的运动模式。数据以频率和百分比表示，并通过Pearson卡方检验或Fisher精确检验进行推断。
■记录了700名被诊断为EoE的患者，其中，38例患者接受了食管HRM。这些患者中有58％被发现在HRM上有食管运动异常。37％的患者在泛食管加压下没有蠕动，但整合松弛压力正常；21％的患者表现出蠕动功能障碍；42％的患者HRM正常。71％的泛食道加压患者出现食物嵌塞，需要进行内窥镜检查以减少食道扩张（P=0.015）。
■最常见的异常是泛食道加压症。这种异常与需要内窥镜干预的推注嵌塞的临床表现相关（P=0.015）。
■一项回顾性研究，在研究期间，所有18岁以上经内镜和组织学诊断为EoE并接受HRM的成年患者均纳入研究。分析了HRM下EoE患者的运动模式。数据以频率和百分比表示，并通过Pearson卡方检验或Fisher精确检验进行推断。
■记录了700名被诊断为EoE的患者，其中，38例患者接受了食管HRM。这些患者中有58％被发现在HRM上有食管运动异常。37％的患者在泛食管加压下没有蠕动，但整合松弛压力正常；21％的患者表现出蠕动功能障碍；42％的患者HRM正常。71％的泛食道加压患者出现食物嵌塞，需要进行内窥镜检查以减少食道扩张（P=0.015）。
■最常见的异常是泛食道加压症。这种异常与需要内窥镜干预的推注嵌塞的临床表现相关（P=0.015）。
