特发性炎性肌病相关间质性肺病(AE-IIM-ILD)的急性加重是与发病率和死亡率增加相关的重要事件。然而,少数研究调查了导致AE-IIM-ILD患者死亡的潜在预后因素.
■我们的研究目的是全面调查高分辨率计算机断层扫描(HRCT)结果是否能预测AE-IIM-ILD患者的1年死亡率。
■回顾性创建69例AE-IIM-ILD患者的队列。该队列是79.7%的女性,平均年龄50.7岁.几种HRCT特征,包括总间质性肺病程度(TIDE),分布模式,和放射学ILD模式,被评估。使用有向无环图(DAG)来评估变量之间的统计关系。使用Cox回归方法来确定与死亡率相关的潜在预后因素。
■与AE-IIM-ILD死亡率显着相关的HRCT发现包括TIDE(HR每增加10%,1.64;95CI,1.29-2.1,p<0.001;模型1:C指数,0.785),弥散分布模式(HR,3.75,95CI,1.5-9.38,p=0.005;模型2:C指数,0.737),和放射学弥漫性肺泡损伤(DAD)模式(HR,6.37,95%CI,0.81-50.21,p=0.079;模型3:C指数,0.735).潮流大于58.33%,漫反射分布模式,放射学DAD模式与不良预后相关。90天,180天,AE-IIM-ILD患者的1年生存率为75.3%,66.3%,和63.3%,分别。
■HRCT发现,包括潮汐,分布模式,和放射学模式,预测经历AE-IIM-ILD的患者的1年死亡率。
UNASSIGNED: Acute exacerbation of idiopathic inflammatory myopathies-associated interstitial lung disease (AE-IIM-ILD) is a significant event associated with increased morbidity and mortality. However, few studies investigated the potential prognostic factors contributing to mortality in patients who experience AE-IIM-ILD.
UNASSIGNED: The purpose of our study was to comprehensively investigate whether high-resolution computed tomography (HRCT) findings predict the 1-year mortality in patients who experience AE-IIM-ILD.
UNASSIGNED: A cohort of 69 patients with AE-IIM-ILD was retrospectively created. The cohort was 79.7 % female, with a mean age of 50.7. Several HRCT features, including total interstitial lung disease extent (TIDE), distribution patterns, and radiologic ILD patterns, were assessed. A directed acyclic graph (DAG) was used to evaluate the statistical relationship between variables. The Cox regression method was performed to identify potential prognostic factors associated with mortality.
UNASSIGNED: The HRCT findings significantly associated with AE-IIM-ILD mortality include TIDE (HR per 10%-increase, 1.64; 95%CI, 1.29-2.1, p < 0.001; model 1: C-index, 0.785), diffuse distribution pattern (HR, 3.75, 95%CI, 1.5-9.38, p = 0.005; model 2: C-index, 0.737), and radiologic diffuse alveolar damage (DAD) pattern (HR, 6.37, 95 % CI, 0.81-50.21, p = 0.079; model 3: C-index, 0.735). TIDE greater than 58.33 %, diffuse distribution pattern, and radiologic DAD pattern correlate with poor prognosis. The 90-day, 180-day, and 1-year survival rates of patients who experience AE-IIM-ILD were 75.3 %, 66.3 %, and 63.3 %, respectively.
UNASSIGNED: HRCT findings, including TIDE, distribution pattern, and radiological pattern, are predictive of 1-year mortality in patients who experience AE-IIM-ILD.