背景:现代世界面临着对意外辐射事件可能性的日益关注。造血系统特别容易受到辐射诱导的细胞凋亡,会导致死亡.二甲双胍,一种治疗糖尿病的药物,已被证明可以保护正常细胞和组织免受辐射的毒性作用。本研究旨在评估二甲双胍减轻大鼠胃肠道和血液系统辐射损伤的有效性。
方法:本研究涉及73只雄性大鼠。在全身照射7.5GyX射线后,大鼠用二甲双胍治疗。七天后,处死大鼠,采集血样进行评价.
结果:研究发现二甲双胍不能有效减轻放射损伤。组织病理学评估显示杯状细胞损伤无明显变化,绒毛缩短,炎症,或粘液层厚度。在生化评价方面,二甲双胍没有显著影响氧化应激标志物,但是照射增加了照射组的平均MDA水平。全血细胞计数显示白细胞和血小板显著减少,与对照组相比,放射组的计数,但放疗组和放疗+二甲双胍组之间无显著差异。
结论:结论:二甲双胍可能不是降低意外暴露后辐射毒性的好选择.尽管治疗,血小板没有改善,白细胞,和淋巴细胞计数,氧化应激也没有减少。需要进一步的研究来探索其他潜在的辐射损伤治疗方法。
BACKGROUND: The modern world faces a growing concern about the possibility of accidental radiation events. The Hematopoietic system is particularly vulnerable to radiationinduced apoptosis, which can lead to death. Metformin, a drug used to treat diabetes, has been shown to protect normal cells and tissues from the toxic effects of radiation. This study aimed to evaluate the effectiveness of metformin in mitigating radiation injury to the gastrointestinal and hematological systems of rats.
METHODS: The study involved 73 male rats. After total body irradiation with 7.5 Gy of X-rays, rats were treated with metformin. Seven days later, the rats were sacrificed and blood samples were taken for evaluation.
RESULTS: The study found that metformin was not effective in mitigating radiation injury. The histopathological assessment showed no significant changes in goblet cell injury, villi shortening, inflammation, or mucous layer thickness. In terms of biochemical evaluation, metformin did not significantly affect oxidative stress markers, but irradiation increased the mean MDA level in the radiation group. The complete blood count revealed a significant decrease in WBC and platelet, counts in the radiation group compared to the control group, but no significant difference was found between the radiation and radiation + metformin groups.
CONCLUSIONS: In conclusion, metformin may not be a good option for reducing radiation toxicity after accidental exposure. Despite treatment, there was no improvement in platelet, white blood cell, and lymphocyte counts, nor was there any decrease in oxidative stress. Further research is needed to explore other potential treatments for radiation injury.