Heat stress disorders

热应激障碍
  • 文章类型: Systematic Review
    目标:全球变暖导致极端高温事件的数量和强度增加,对工人的健康和安全构成重大威胁,尤其是那些在户外工作的人,因为他们经常有限地使用冷却策略。本系统文献综述(a)总结了当前关于气候变化对户外工人影响的知识,(b)提供关于这个问题的历史背景,(c)探讨减少和增加热应力复原力的因素,(d)讨论缓解热量的战略,(e)概述户外工人职业热暴露的现行政策和法律框架。
    方法:在这篇系统综述中,我们搜索了包括Scopus(N=855)在内的科学数据库,WebofScience(N=828),和PubMed(N=202)。此外,我们通过GoogleScholar(N=116)使用特定的搜索词确定了有关气候变化和热应力控制措施的相关研究。总的来说,我们监测了2001年有关14个国家各种室外气候条件下工人人口(男性=2921;女性=627)的文章。经过全文评估,55项研究入选,最后,纳入29篇符合条件的论文进行数据提取。
    结果:未能对户外工人实施有效的控制策略将导致对热应力的抵抗力下降。调查结果强调,人们缺乏对某些适应战略和干预措施的认识,这些战略和干预措施旨在预防和增强应对气候变化对户外热带和亚热带环境中工人热应激流行率的影响。然而,在热应激恢复能力的总体评估中,从经济和生态可持续性方面有吸引力的替代解决方案可以称为适应,阴影,优化服装性能和计划休息。
    结论:将气候变化适应策略纳入职业健康计划可以增强户外工人的职业热恢复力。对于低收入和中等收入的热带和亚热带国家的专业人员和决策者来说,对户外工人的热应力适应策略进行健康和安全措施的成本效益评估至关重要。在这方面,针对水合作用的补充措施,工作休息制度,通风服装,自我起搏,可以采用机械化来保护户外工人。风险管理战略,适应性措施,热风险意识,实际干预,培训计划,应在炎热干燥和炎热潮湿的气候中实施保护政策,以提高户外工人的容忍度和韧性。
    OBJECTIVE: Global warming has led to an increase in the number and intensity of extreme heat events, posing a significant threat to the health and safety of workers, especially those working outdoors, as they often have limited access to cooling strategies. The present systematic literature review (a) summarizes the current knowledge on the impacts of climate change on outdoor workers, (b) provides historical background on this issue, (c) explores factors that reduce and increase thermal stress resilience, (d) discusses the heat mitigation strategies, and (e) provides an overview of existing policy and legal frameworks on occupational heat exposure among outdoor workers.
    METHODS: In this systematic review, we searched scientific databases including Scopus (N = 855), Web of Science (N = 828), and PubMed (N = 202). Additionally, we identified relevant studies on climate change and heat-stress control measures through Google Scholar (N = 116) using specific search terms. In total, we monitored 2001 articles pertaining to worker populations (men = 2921; women = 627) in various outdoor climate conditions across 14 countries. After full-text assessment, 55 studies were selected for inclusion, and finally, 29 eligible papers were included for data extraction.
    RESULTS: Failure to implement effective control strategies for outdoor workers will result in decreased resilience to thermal stress. The findings underscore a lack of awareness regarding certain adaptation strategies and interventions aimed at preventing and enhancing resilience to the impact of climate change on heat stress prevalence among workers in outdoor tropical and subtropical environments. However, attractive alternative solutions from the aspects of economic and ecological sustainability in the overall assessment of heat stress resilience can be referred to acclimatization, shading, optimized clothing properties and planned breaks.
    CONCLUSIONS: The integration of climate change adaptation strategies into occupational health programs can enhance occupational heat resilience among outdoor workers. Conducting cost-benefit evaluations of health and safety measures for thermal stress adaptation strategies among outdoor workers is crucial for professionals and policymakers in low- and middle-income tropical and subtropical countries. In this respect, complementary measures targeting hydration, work-rest regimes, ventilated garments, self-pacing, and mechanization can be adopted to protect outdoor workers. Risk management strategies, adaptive measures, heat risk awareness, practical interventions, training programs, and protective policies should be implemented in hot-dry and hot-humid climates to boost the tolerance and resilience of outdoor workers.
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  • 文章类型: Journal Article
    由于全球气温上升,与热有关的疾病的发病率越来越高。与热有关的疾病从轻度到重度不等,中暑是最关键的.湿球温度指数考虑了湿度和太阳强度;建议使用它来估计个人的热应力并减轻风险。高效的冷却方法,如冷水浸泡,在严重的情况下是必不可少的。预防是通过水合,合适的衣服,识别高风险药物,和对环境条件的认识。在临床过程中及早认识到与热有关的疾病并实施快速降温策略可降低发病率和死亡率。
    There is a growing incidence of heat-related illnesses due to rising global temperatures. Heat-related illnesses range from mild to severe, with heat stroke being the most critical. The wet bulb global temperature index considers humidity and solar intensity; its use is recommended to estimate heat stress on an individual and mitigate risk. Efficient cooling methods, such as cold water immersion, are essential in severe cases. Prevention is through hydration, appropriate clothing, recognition of high risk medications, and awareness of environmental conditions. Recognizing heat-related illnesses early in the clinical course and implementing rapid cooling strategies reduces morbidity and mortality.
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  • 文章类型: Journal Article
    与其他地区相比,台湾的透析发病率和患病率较高。因此,在台湾,减轻慢性肾脏病(CKD)和肾功能恶化已成为重要的医疗优先事项.已知热应激是CKD和肾功能损害的重要危险因素。然而,男性和女性之间热应激影响的差异仍未被探索。我们使用台湾生物库(TWB)的数据进行了回顾性横断面分析,根据参与者的住址,纳入中午(上午11点至下午2点)和工作时间(上午8点至下午5点)期间的湿球温度(WBGT)记录。平均1-,3-,并使用基于地理空间人工智能的集成混合空间模型计算和分析了调查年之前的5年WBGT值,涵盖2010年至2020年期间。共有114,483名来自TWB的参与者参加了这项研究。其中35.9%为男性,1053例肾功能受损(定义为估计肾小球滤过率<60ml/min/1.73m2)。多变量分析表明,在男性参与者中,在中午期间,1-,3-,和5年平均每增加1℃的WBGT值与eGFR<60ml/min/1.73m2(比值比[OR],1.096,95%置信区间[CI]=1.002-1.199,1年p=0.044;OR,1.093,95%CI=1.000-1.196,3年p=0.005;OR,1.094,95%CI=1.002-1.195,5年p=0.045)。然而,在工作时间期间没有发现显著的关联.在女性参与者中,在中午期间,1-,3-,5年平均WBGT值每增加1℃与eGFR<60ml/min/1.73m2(OR,0.872,95%CI=0.778-0.976,1年p=0.018;OR,0.874,95%CI=0.780-0.978,3年p=0.019;OR,0.875,95%CI=0.784-0.977,5年p=0.018)。此外,在工作时间期间,1-,3-,5年平均WBGT值每增加1℃也与eGFR<60ml/min/1.73m2(OR,0.856,95%CI=0.774-0.946,1年p=0.002;OR,0.856,95%CI=0.774-0.948,3年p=0.003;OR,0.853,95%CI=0.772-0.943,5年p=0.002)。总之,我们的结果显示,男性WBGT增加与肾功能受损有关,而增加的WBGT与女性肾功能受损的保护作用相关。需要进一步的研究来阐明这些性别特异性差异的确切机制。
    The incidence and prevalence of dialysis in Taiwan are high compared to other regions. Consequently, mitigating chronic kidney disease (CKD) and the worsening of kidney function have emerged as critical healthcare priorities in Taiwan. Heat stress is known to be a significant risk factor for CKD and kidney function impairment. However, differences in the impact of heat stress between males and females remains unexplored. We conducted this retrospective cross-sectional analysis using data from the Taiwan Biobank (TWB), incorporating records of the wet bulb globe temperature (WBGT) during midday (11 AM-2 PM) and working hours (8 AM-5 PM) periods based on the participants\' residential address. Average 1-, 3-, and 5-year WBGT values prior to the survey year were calculated and analyzed using a geospatial artificial intelligence-based ensemble mixed spatial model, covering the period from 2010 to 2020. A total of 114,483 participants from the TWB were included in this study, of whom 35.9% were male and 1053 had impaired kidney function (defined as estimated glomerular filtration rate < 60 ml/min/1.73 m2). Multivariable analysis revealed that in the male participants, during the midday period, the 1-, 3-, and 5-year average WBGT values per 1 ℃ increase were significantly positively associated with eGFR < 60 ml/min/1.73 m2 (odds ratio [OR], 1.096, 95% confidence interval [CI] = 1.002-1.199, p = 0.044 for 1 year; OR, 1.093, 95% CI = 1.000-1.196, p = 0.005 for 3 years; OR, 1.094, 95% CI = 1.002-1.195, p = 0.045 for 5 years). However, significant associations were not found for the working hours period. In the female participants, during the midday period, the 1-, 3-, and 5-year average WBGT values per 1 ℃ increase were significantly negatively associated with eGFR < 60 ml/min/1.73 m2 (OR, 0.872, 95% CI = 0.778-0.976, p = 0.018 for 1 year; OR, 0.874, 95% CI = 0.780-0.978, p = 0.019 for 3 years; OR, 0.875, 95% CI = 0.784-0.977, p = 0.018 for 5 years). In addition, during the working hours period, the 1-, 3-, and 5-year average WBGT values per 1 ℃ increase were also significantly negatively associated with eGFR < 60 ml/min/1.73 m2 (OR, 0.856, 95% CI = 0.774-0.946, p = 0.002 for 1 year; OR, 0.856, 95% CI = 0.774-0.948, p = 0.003 for 3 years; OR, 0.853, 95% CI = 0.772-0.943, p = 0.002 for 5 years). In conclusion, our results revealed that increased WBGT was associated with impaired kidney function in males, whereas increased WBGT was associated with a protective effect against impaired kidney function in females. Further studies are needed to elucidate the exact mechanisms underlying these sex-specific differences.
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  • 文章类型: Journal Article
    该研究旨在建立奶牛的异常体温概率(ABTP)模型,利用环境和生理数据。该模型旨在加强对热应力影响的管理,为农场管理者提供早期预警系统,以改善奶牛福利和农场生产力,以应对气候变化。该研究采用最小绝对收缩和选择算子(LASSO)算法分析了320头奶牛的环境和生理数据,确定影响体温异常的关键因素。此方法支持各种模型的开发,包括LymanKutcher-Burman(LKB),物流,Schultheiss,和泊松模型,评估它们有效预测奶牛异常体温的能力。该研究成功验证了预测奶牛体温异常的多个模型,重点是温度-湿度指数(THI)作为关键决定因素。这些模型,包括LKB,物流,Schultheiss,和Poisson,证明了高精度,通过AUC和其他性能指标(如Brier评分和Hosmer-Lemeshow(HL)测试)来衡量。结果突出了模型在捕获热应激对奶牛影响的细微差别方面的稳健性。该研究开发了控制奶牛热应激的创新模型,有效加强检测和干预策略。通过整合先进技术和新颖的预测模型,这项研究提供了早期发现和管理异常体温的有效措施,在不断变化的气候条件下提高牛的福利和农场生产力。这种方法突出了使用多个模型来准确预测和解决牲畜热应激的重要性,为加强农场管理实践做出重大贡献。
    The study aims to develop an abnormal body temperature probability (ABTP) model for dairy cattle, utilizing environmental and physiological data. This model is designed to enhance the management of heat stress impacts, providing an early warning system for farm managers to improve dairy cattle welfare and farm productivity in response to climate change. The study employs the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm to analyze environmental and physiological data from 320 dairy cattle, identifying key factors influencing body temperature anomalies. This method supports the development of various models, including the Lyman Kutcher-Burman (LKB), Logistic, Schultheiss, and Poisson models, which are evaluated for their ability to predict abnormal body temperatures in dairy cattle effectively. The study successfully validated multiple models to predict abnormal body temperatures in dairy cattle, with a focus on the temperature-humidity index (THI) as a critical determinant. These models, including LKB, Logistic, Schultheiss, and Poisson, demonstrated high accuracy, as measured by the AUC and other performance metrics such as the Brier score and Hosmer-Lemeshow (HL) test. The results highlight the robustness of the models in capturing the nuances of heat stress impacts on dairy cattle. The research develops innovative models for managing heat stress in dairy cattle, effectively enhancing detection and intervention strategies. By integrating advanced technologies and novel predictive models, the study offers effective measures for early detection and management of abnormal body temperatures, improving cattle welfare and farm productivity in changing climatic conditions. This approach highlights the importance of using multiple models to accurately predict and address heat stress in livestock, making significant contributions to enhancing farm management practices.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    本文简要概述了与热有关的疾病,强调其对公共卫生的重大影响。它探讨了从轻度热痉挛到危及生命的中暑的病理生理学,强调关键的传热机制和环境因素的重要性。鉴别诊断注意事项,预防策略,并讨论了护理影响,强调需要迅速认识和干预管理这些条件。
    UNASSIGNED: This article concisely overviews heat-related illnesses, emphasizing their significant impact on public health. It explores the pathophysiology of conditions ranging from mild heat cramps to life-threatening heat stroke, highlighting key heat transfer mechanisms and the importance of environmental factors. Differential diagnosis considerations, prevention strategies, and nursing implications are discussed, underscoring the need for prompt recognition and intervention in managing these conditions.
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  • 文章类型: Journal Article
    背景:非洲城市,特别是阿比让和约翰内斯堡,面对城市快速增长的挑战,非正式和紧张的卫生服务,气候变化导致温度升高。这项研究旨在了解这些城市与热相关的健康影响的复杂性。目标是:(1)使用健康绘制城市内热风险和暴露图,社会经济,气候和卫星图像数据;(2)建立分层热健康预测模型,以预测不良健康结果;(3)建立早期预警系统,以及时发出热浪警报。最终目标是培育具有气候适应性的非洲城市,保护不成比例的受影响人群免受热危害。
    方法:该研究将从2000年至2022年在约翰内斯堡和阿比让进行的合格成人临床试验或队列研究中获取健康相关数据集。将收集更多数据,包括社会经济,气候数据集和卫星图像。这些资源将有助于绘制热危害图并量化热健康暴露,风险和发病率升高的程度。结果将使用先进的数据分析方法来确定,包括统计评估,机器学习和深度学习技术。
    背景:该研究已获得Wits人类研究伦理委员会的批准(参考号:220606)。数据管理将遵循批准的程序。结果将通过讲习班传播,社区论坛,会议和出版物。将根据道德和安全考虑制定数据存储和管理计划。
    BACKGROUND: African cities, particularly Abidjan and Johannesburg, face challenges of rapid urban growth, informality and strained health services, compounded by increasing temperatures due to climate change. This study aims to understand the complexities of heat-related health impacts in these cities. The objectives are: (1) mapping intraurban heat risk and exposure using health, socioeconomic, climate and satellite imagery data; (2) creating a stratified heat-health forecast model to predict adverse health outcomes; and (3) establishing an early warning system for timely heatwave alerts. The ultimate goal is to foster climate-resilient African cities, protecting disproportionately affected populations from heat hazards.
    METHODS: The research will acquire health-related datasets from eligible adult clinical trials or cohort studies conducted in Johannesburg and Abidjan between 2000 and 2022. Additional data will be collected, including socioeconomic, climate datasets and satellite imagery. These resources will aid in mapping heat hazards and quantifying heat-health exposure, the extent of elevated risk and morbidity. Outcomes will be determined using advanced data analysis methods, including statistical evaluation, machine learning and deep learning techniques.
    BACKGROUND: The study has been approved by the Wits Human Research Ethics Committee (reference no: 220606). Data management will follow approved procedures. The results will be disseminated through workshops, community forums, conferences and publications. Data deposition and curation plans will be established in line with ethical and safety considerations.
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  • 文章类型: Journal Article
    褪黑激素(MT)是由身体分泌的具有抗氧化和抗炎特性的胺激素。本研究的目的是研究MT对热应激鸡的病理生理保护作用。通过对热应激鸡建模并用MT处理。给药21天后,血清抗氧化酶,生化指标,检测炎性细胞因子和热应激指标,以及鸡的心肺功能指标和组织学观察。结果表明,热应激引起的体重下降(P<0.05)和体温升高,在MT干预后被逆转。MT治疗可抑制促炎因子白细胞介素-1β的分泌(P<0.05),白细胞介素-6,肿瘤坏死因子α,血清热休克蛋白70,皮质酮,生化因子总蛋白水平升高(P<0.05),白蛋白,球蛋白,并增加了抗氧化酶超氧化物歧化酶的活性(P<0.05),热应激引起的鸡血清中的谷胱甘肽过氧化物酶和过氧化氢酶,中剂量MT效果最佳。热应激导致心脏萎缩和肺充血,肌酸激酶同工酶降低(P<0.05),心肌肌钙蛋白I,血管紧张素受体I,肌酸激酶和肺功能指标髓过氧化物酶,血管紧张素II,热冲击因子I,并升高(P<0.05)肺血管内皮生长因子Ⅱ。观察到施用MT后心脏和肺的切片更完整,组织指数更正常。同时,与热应激相比,MT给药后,分级鸡的心肺功能指标显著降低(P<0.05),趋于正常水平,中剂量MT效果最佳。总之,热应激可引起鸡的病理生理损伤,1mg/kg/d的外源性褪黑素可以减轻这种不良作用。
    Melatonin (MT) is an amine hormone secreted by the body that has antioxidant and anti-inflammatory properties. The aim of this study was to investigate pathophysiological protection of MT in heat-stressed chickens. By modelling heat-stressed chickens and treating them with MT. After 21 days of administration, serum antioxidant enzymes, biochemical indices, inflammatory cytokine and heat-stress indices were detected, along with cardiopulmonary function indices and histological observations in chickens. The results show heat-stress induced a decrease (P < 0.05) in body weight and an increase in body temperature, which was reversed after MT intervention. Treatment with MT inhibited (P < 0.05) the secretion of pro-inflammatory factors interleukin-1β, interleukin-6, tumor necrosis factor α, serum heat shock protein 70, corticosterone, and elevated (P < 0.05) the levels of biochemical factors total protein, albumin, globulin, and increased (P < 0.05) the activities of antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase in chicken serum caused by heat stress, and the best effect was observed with the medium dose of MT. The heat-stress caused cardiac atrophy and pulmonary congestion, decreased (P < 0.05) the cardiac function indices creatine kinase isoenzyme, cardiac troponin I, angiotensin receptor I, creatine kinase and lung function indices myeloperoxidase, angiotensin-II, heat shock factor I, and increased (P < 0.05) the lung vascular endothelial growth factor II. Sections of the heart and lungs after administration of MT were observed to be more complete with more normal tissue indices. At the same time, compared with heat stress, heart and lung function indices of grade chickens after MT administration were significantly (P < 0.05)reduced and tended to normal levels, and the best effect was observed in the medium-dose MT. In conclusion, heat stress can cause pathophysiological damage in chickens, and 1 mg/kg/d of exogenous melatonin can attenuate this adverse effect.
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  • 文章类型: Journal Article
    老年人容易受到热的不利健康影响。由于出汗能力降低和皮肤血流量减少,他们的体温调节受损,并且更有可能患有疾病,在炎热的天气里有恶化的风险。因此,老年人应该在炎热的天气中适应他们的行为,并采用水循环冷却策略。理想情况下,在热浪期间,应每天与他们联系以寻求支持并检查他们的健康状况。卫生专业人员应进行夏季前的体检,并告知热量健康风险和预防策略。
    Elderly are vulnerable to adverse health effects of heat. They have impaired thermoregulation due to lower ability to sweat and decreased skin blood flow and are more likely to have diseases, which carry a risk for exacerbation during hot weather. Therefore, elderly should adapt their behavior during hot weather and apply water-bound cooling strategies. Ideally, they should be contacted daily during heatwaves for support and to check up on their health status. Health professionals should conduct a pre-summer medical check-up and inform about heat health risks and prevention strategies.
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