目的:研究健康的睡眠模式是否会降低高血压患者心脏代谢多发病(CMM)的风险。
方法:这是来自英国生物银行的前瞻性队列分析。共有69524例无糖尿病史的高血压患者,冠心病,纳入基线时的卒中或卒中。基线健康睡眠的五个维度,包括早期时间型,睡眠7-8小时/天,没有失眠,没有打鼾,并且没有使用频繁的白天过度嗜睡来产生0至5的健康睡眠评分(健康睡眠的每个维度都给出1分).较高的分数表明更健康的睡眠模式。我们设置五组对应的健康睡眠评分分别为5、4、3、2和0-1。主要结果是登记的高血压患者中整体CMM的发生率。我们通过Fine-Gray子分布风险模型评估了调整后的风险比(HR)和95%置信区间(CI)。
结果:我们发现,健康睡眠评分增加1分,总体CMM的全校正HR(95%CI)为0.93(0.91-0.95)。与健康睡眠评分为0-1的高血压相比,评分为5的高血压患者的总体CMM风险降低了27%,37%,23%,糖尿病风险降低20%,冠心病,和中风,分别,在调整了社会人口统计学特征后,生活方式,和临床因素。
结论:我们的结果表明,在高血压患者中,健康的睡眠模式与较低的CMM结局风险相关。
To investigate whether a healthy sleep pattern would reduce the risk of cardiometabolic multimorbidity (CMM) among hypertensives.
This is a prospective cohort analysis from the UK Biobank. A total of 69 524 hypertensives without a history of diabetes mellitus, coronary heart disease, or stroke at baseline were enrolled. Five dimensions of healthy sleep at baseline including early chronotype, sleep 7-8 h/d, free of insomnia, no snoring, and no frequent excessive daytime sleepiness were used to generate a healthy sleep score ranging from 0 to 5 (one point was given for each dimension of healthy sleep). A higher score indicated a healthier sleep pattern. We set five groups corresponding to the healthy sleep score of 5, 4, 3, 2, and 0-1, respectively. The primary outcome was the incidence of overall CMM among enrolled hypertensives. We assessed the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) by Fine-Gray subdistribution hazard models.
We found the full-adjusted HR (95% CI) for overall CMM was 0.93 (0.91-0.95) for a 1-point increase in the healthy sleep score. Compared to hypertensives with a healthy sleep score of 0-1, those with a score of 5 had a 27% lower risk of overall CMM, and 37%, 23%, and 20% lower risks of diabetes mellitus, coronary heart disease, and stroke, respectively, after adjusting for sociodemographic characteristic, lifestyle, and clinical factors.
Our results indicated that a healthy sleep pattern was associated with lower risks of CMM outcomes among hypertensives.