PDF(Pubmed)
Abstract：
OBJECTIVE: Evidence on the link between sleep patterns and cardiovascular diseases (CVDs) in the community essentially relies on studies that investigated one single sleep pattern at one point in time. This study examined the joint effect of five sleep patterns at two time points with incident CVD events.
METHODS: By combining the data from two prospective studies, the Paris Prospective Study III (Paris, France) and the CoLaus|PsyCoLaus study (Lausanne, Switzerland), a healthy sleep score (HSS, range 0-5) combining five sleep patterns (early chronotype, sleep duration of 7-8 h/day, never/rarely insomnia, no sleep apnoea, and no excessive daytime sleepiness) was calculated at baseline and follow-up.
RESULTS: The study sample included 11 347 CVD-free participants aged 53-64 years (44.6% women). During a median follow-up of 8.9 years [interquartile range (IQR): 8.0-10.0], 499 first CVD events occurred (339 coronary heart disease (CHD) and 175 stroke). In multivariate Cox analysis, the risk of CVD decreased by 18% [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.76-0.89] per one-point increment in the HSS. After a median follow-up of 6.0 years (IQR: 4.0-8.0) after the second follow-up, 262 first CVD events occurred including 194 CHD and 72 stroke. After adjusting for baseline HSS and covariates, the risk of CVD decreased by 16% (HR 0.84, 95% CI 0.73-0.97) per unit higher in the follow-up HSS over 2-5 years.
CONCLUSIONS: Higher HSS and HSS improvement over time are associated with a lower risk of CHD and stroke in the community.
METHODS: By combining the data from two prospective studies, the Paris Prospective Study III (Paris, France) and the CoLaus|PsyCoLaus study (Lausanne, Switzerland), a healthy sleep score (HSS, range 0-5) combining five sleep patterns (early chronotype, sleep duration of 7-8 h/day, never/rarely insomnia, no sleep apnoea, and no excessive daytime sleepiness) was calculated at baseline and follow-up.
RESULTS: The study sample included 11 347 CVD-free participants aged 53-64 years (44.6% women). During a median follow-up of 8.9 years [interquartile range (IQR): 8.0-10.0], 499 first CVD events occurred (339 coronary heart disease (CHD) and 175 stroke). In multivariate Cox analysis, the risk of CVD decreased by 18% [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.76-0.89] per one-point increment in the HSS. After a median follow-up of 6.0 years (IQR: 4.0-8.0) after the second follow-up, 262 first CVD events occurred including 194 CHD and 72 stroke. After adjusting for baseline HSS and covariates, the risk of CVD decreased by 16% (HR 0.84, 95% CI 0.73-0.97) per unit higher in the follow-up HSS over 2-5 years.
CONCLUSIONS: Higher HSS and HSS improvement over time are associated with a lower risk of CHD and stroke in the community.
摘要：
目的：关于社区中睡眠模式与心血管疾病（CVD）之间联系的证据基本上依赖于在某个时间点调查一种单一睡眠模式的研究。这项研究检查了五种睡眠模式在两个时间点与CVD事件的联合作用。
方法：通过结合两项前瞻性研究的数据，巴黎前瞻性研究III(巴黎，法国)和CoLaus|PsyCoLaus研究(洛桑，瑞士),健康的睡眠评分(HSS，范围0-5)结合五种睡眠模式(早期时间型，睡眠时间7-8小时/天，从不/很少失眠，没有睡眠呼吸暂停,在基线和随访时计算出白天没有过度嗜睡）。
结果：研究样本包括11347名年龄在53-64岁之间的无心血管疾病参与者（44.6%为女性）。在8.9年的中位随访期间[四分位数间距（IQR）：8.0-10.0]，发生了499起首次CVD事件（339起冠心病（CHD）和175起卒中）。在多变量Cox分析中，HSS每增加1分,CVD风险降低18%[风险比(HR)0.82,95%置信区间(CI)0.76-0.89].第二次随访后，中位随访6.0年（IQR：4.0-8.0），发生了262次首次CVD事件，包括194次CHD和72次中风。在调整基线HSS和协变量后，在2~5年的HSS随访中,CVD风险每单位降低16%(HR0.84,95%CI0.73~0.97).
结论：随着时间的推移，较高的HSS和HSS改善与社区冠心病和卒中风险较低相关。
方法：通过结合两项前瞻性研究的数据，巴黎前瞻性研究III(巴黎，法国)和CoLaus|PsyCoLaus研究(洛桑，瑞士),健康的睡眠评分(HSS，范围0-5)结合五种睡眠模式(早期时间型，睡眠时间7-8小时/天，从不/很少失眠，没有睡眠呼吸暂停,在基线和随访时计算出白天没有过度嗜睡）。
结果：研究样本包括11347名年龄在53-64岁之间的无心血管疾病参与者（44.6%为女性）。在8.9年的中位随访期间[四分位数间距（IQR）：8.0-10.0]，发生了499起首次CVD事件（339起冠心病（CHD）和175起卒中）。在多变量Cox分析中，HSS每增加1分,CVD风险降低18%[风险比(HR)0.82,95%置信区间(CI)0.76-0.89].第二次随访后，中位随访6.0年（IQR：4.0-8.0），发生了262次首次CVD事件，包括194次CHD和72次中风。在调整基线HSS和协变量后，在2~5年的HSS随访中,CVD风险每单位降低16%(HR0.84,95%CI0.73~0.97).
结论：随着时间的推移，较高的HSS和HSS改善与社区冠心病和卒中风险较低相关。
