背景:实体器官移植受者在器官移植后的癌症风险高于年龄调整后的普通人群。我们评估了心脏头颈部鳞状细胞癌(HNSCC)的发病率,肺,和肝脏接受者。
■这项回顾性队列研究包括来自美国移植接受者科学注册(SRTR)数据库的124,966名患者,他们接受了心脏,肺,或1991年至2010年之间的肝移植。随访数据一直到2018年。排除移植时流行HNSCC的患者。确定了器官移植后HNSCC的事件病例,和发病率(每100,000人年)按性别报告,种族,器官类型,器官移植的年龄和年龄。
结果:大多数患者接受了肝移植(58.64%),其次是心脏(28.64%),和肺(12.72%)移植。随访期间,4.14%患者发生HNSCC。HNSCC的总发病率为426.76/100,000人年。男性接受者的HNSCC发病率高于女性接受者(每100,000人年571.8和177.0,分别)。肺部受者的总体HNSCC发病率最高(每100,000人年1273.6),其次是心脏(每10万人年644.2),和肝脏接受者(每100,000人年207.1)。总的来说,随着器官移植时年龄的增加,HNSCC发病率增加.随着时间的推移,在肺部受者中观察到HNSCC的发病率增加;然而,随着时间的推移,心脏接受者的发病率下降。
结论:实体器官移植受者在器官移植后HNSCC的发生率很高,发病率因接受的器官类型而异。
BACKGROUND: Solid organ transplant recipients have an elevated risk of cancer following organ transplantation than the age-adjusted general population. We assessed incidence of head and neck squamous cell carcinoma (HNSCC) in heart, lung, and liver recipients.
UNASSIGNED: This retrospective cohort study included 124,966 patients from the United States Scientific Registry of Transplant Recipients (SRTR) database who received heart, lung, or liver transplantation between 1991 and 2010. Follow-up data were available until 2018. Patients with prevalent HNSCC at transplantation were excluded. Incident cases of HNSCC post organ transplantation were identified, and incidence rates (per 100,000 person-years) were reported by gender, race, organ type, year and age at organ transplantation.
RESULTS: The majority of patients received liver transplantation (58.64 %), followed by heart (28.64 %), and lung (12.72 %) transplantation. During follow-up, 4.14 % patients developed HNSCC. Overall incidence rate of HNSCC was 426.76 per 100,000 person-years. Male recipients had a higher HNSCC incidence rate than female recipients (571.8 and 177.0 per 100,000 person-years, respectively). Lung recipients had the highest overall HNSCC incidence rate (1273.6 per 100,000 person-years), followed by heart (644.2 per 100,000 person-years), and liver recipients (207.1 per 100,000 person-years). Overall, an increase in HNSCC incidence rate was observed with increase in age at organ transplantation. An increase in incidence rates of HNSCC over time was observed in lung recipients; however, incidence rates decreased over time in heart recipients.
CONCLUSIONS: Solid organ transplant recipients have a high incidence of HNSCC following organ transplantation, and the incidence varies by type of organ received.